Table 6.

Characteristics of Pain Cortical Matrices

	Primary Cortical Pain Matrix	Secondary Cortical Pain Matrix	Third Cortical Pain Matrix
Structures	Primary somatosensory Secondary somatosensory Parietal operculum Posterior insula	Anterior cingulate cortex Anterior insula Amygdala Hippocampus	Frontal cortex (orbitofrontal, anterolateral, prefrontal) Medial cingulate Posterior cingulate
Function	Pain perception Pain localization Pain quality Pain Intensity	Affective experience Emotional experience Negative emotions Distress Unpleasantness	Cognitive meaning Behavioral response