Figure 4.

Voxelwise regression and normative resting state connectivity: local SBR voxels within the DaTStriatum volume significantly associated with UES (A) and online learning (B). Significant voxels are coloured (n = 38, t-test FWE-corrected at cluster-level; P < 0.05). The significant cluster for online learning is highlighted with a dotted square (in slices corresponding to z-coordinate 8, 11 and 14) and the largest cluster (at z-coordinate 11) is depicted at the inset on the left side of the panel. (C) Voxels exhibiting significant resting state connectivity to the striatal ROI set around the peak voxel associated with UES (far left) and online learning (middle; in both panels computed from 100 healthy persons from the human connectome project as detailed in the ‘Materials and methods’ section, t-test FWE-corrected at cluster level P < 0.05). On the far right, the two maps (UES & Online learning) are overlaid (Overlap) with a binary contrast. Note the more posterior connectivity to the supplementary motor area and more M1 involvement for online learning compared to UES. Substantial overlap existed in particular at the level of the basal ganglia. Numbers indicate the MNI z-coordinate of the slices.