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. 2024 Nov 8;14:1474438. doi: 10.3389/fonc.2024.1474438

Table 7.

Practice elements recommendations of multi- gradient individual ERAS (MGI- ERAS).

Items Gradient 1 Gradient 2 Gradient 3
Preadmission information, education and counsellin Simply completed during simple guidan c ERAS group makes the simple guidan c Specialized ERAS group makes systematic guidance on nutrition, smoking cessation, alcohol dependency management, and pulmonary prehabilitation
Airway management after admission Climbing stairs and simple physical pulmonary training guided by surgeons or nurses ERAS group guided the preoperative airway management ERAS group including a specialized physiotherapist guided the preoperative airway management
Aspirin withdrawal or not (routinr minimally invasive surgery with low bleeding ris) Aspirin withdrawal for at least one we Aspirin withdrawal for 3-5 days then LMWHa bringing management No aspirin withdrawal
Preoperative fasting and carbohtdrate treatment Clear fluids be allowed up until 4 hours before the induction of anaesthesia and soilids until 8 hours before induction Oral carbohydrate loading be allowed up until 2-4 hours before the induction of anaesthesia and solids until 8 hours before induction Oral carbohtdrate loading be allowed up until 2 hoursv before the induction of anaesthesia and solids until 6 hours before induction
Preventing intraoperative Hypothermi Temperature control of the operating room during surgery Convective active warming devices used perioperatively Continuous measurement of core temperature to guide the temperature control of the patients.
Urinary drainage (routine minimally invasive segmentectomy surgery without need for strict fluid management) The transurethral catheter is moved immediately after the operation Not routinely placed for patients undergo wedge resection Not routinely placed for lobectomy, even for sleeve lobectomy or tracheal surgery with low bleeding ris
Anaesthetic protoco A combination of regional and general anaesthetic techniques with lung protective strategies during one-lung ventilation Completely tubeless protocolb for patients undergo wedge resection. Completely tubeless protocolb for segmentectomy, lobectomy, even for sleeve lobectomy or tracheal surgery with low bleeding risk.
Surgical techniqu Three- port minimally invasive surgery (including VATS and robotic surgery Two- port minimally invasive surgery (including VATS and robotic surgery) Uniport minimally invasive surgery (including VATS and robotic surgery)
Postoperative recovery  Raising the head of bed (by ≥30°) Sit up straight 4- 6 hours Sit up straight 2 hours after returning to position and mobilization Raising the head of bed (by ≥30°) immediately back to the general ward, patients should be mobilized within 24 hours of surgery Sit up straight 4- 6 hours after returning to the general ward, try to leave the sickbed 6- 8 hours after returning to the general ward Sit up straight 2 hours after returning tothe general ward, moderate ambulationis tried 4 hours after returning to the general ward
Postoperative water drinking and diet Try water drinking 4- 6 hours after returning to the general ward if no PONVc occurs, semi- fluid diet is permitted Try water drinking 2- 4 hours after returning to the general ward, if no PONVc occurs, semi- fluid diet is permitted. The nutrition procedures is better conducted by specialized nutritionists Try water drinking ≤2 hours after returning to the general ward, if no PONVc occurs, semi- fluid diet is permitted. The nutrition procedure is better conducted by specialized nutritionists.
Removal of the chest Tubes Thoracic closed drainage with negative pressure can be use for continuous air leak, chest tubes should be removed with the daily serous effusion without progressive bleeding or chylothorax)≤200ml. Thoracic closed drainage with negative pressure can be used for continuous air leak, chest tubes should be removed with the daily serous effusion (without progressive bleeding or chylothorax)≤300ml. Thoracic closed drainage with negative pressure can be used for continuous air leak, chest tubes should be removed with the daily serous effusion (without progressive bleeding or chylothorax) ≤450ml.
ain relief regim Multimodal analgesic regime is recommended Multimodal analgesic regime with the minimized opioids education and pain management consultation is needed sometimes Multimodal analgesic regime with the minimized opioids dosage, professional psychological counselling for anxious patients and additional techniques such as transcutaneous electrical nerve stimulation carried out by physiotherapist is used.

aLMWH, low molecular weight heparin.

bCompletely tubeless protocol: VATS surgery with both non-intubated intravenous anesthesia and no urinary catheterization protocol.

cPONV, postoperative nausea and vomiting.