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. 2024 Nov 8;15:1490712. doi: 10.3389/fimmu.2024.1490712

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Copyright © 2024 Xia, Han, Sun, Li, Zhu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall design of our study. The nuanced interactions between neutrophils, specifically tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), with key osteosarcoma microenvironment (TME) constituents. It emphasizes the reciprocal modulation between TANs and TME cellular components, such as cancer-associated fibroblasts (CAFs) and regulatory T cells (Tregs), and molecular mediators including cytokines and chemokines, which orchestrate a pro-tumorigenic or tumor-suppressive milieu.