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Function and roles of Tumor-Associated Neutrophils (TANs) in Osteosarcoma. N1 TANs, characterized by their anti-tumoral functions, are depicted engaging in ROS-mediated cytotoxicity and antigen presentation, while N2 TANs are portrayed as pro-tumorigenic, secreting factors such as MMP-9 and VEGF that facilitate angiogenesis and immunosuppression.
