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Post-surgical Neutrophil Activation and Its Implications in Osteosarcoma Metastasis. The post-operative surge in neutrophil activity following osteosarcoma surgery, showcasing the release of damage-associated molecular patterns (DAMPs) and subsequent neutrophil chemotaxis. It suggests a model where surgical stress-induced NETosis and the formation of pre-metastatic niches in distal organs are potential drivers of tumor cell dissemination.
