Table 1.
Studies focusing on the clinical roles of neutrophils in osteosarcoma.
| Index | Sample size | Location | Population Characteristics | Study type | Outcome | Conclusion | Ref |
|---|---|---|---|---|---|---|---|
| Pretreatment Neutrophil count | 65 | Japan | First visit osteosarcoma patients without metastasis | Single-center retrospective study | Metastasis | Low neutrophil count as a risk factor for metastasis of osteosarcoma | (122) |
| Pretreatment NLR | 359 | China | Patients who underwent curative surgery for osteosarcoma | Single-center retrospective study | 5-years OS/PFS | High levels of NLR as risk factors for survival of osteosarcoma | (123) |
| NLR | 2087 | – | Patients with osteosarcoma | Meta-analysis | OS/DFS | High levels of NLR as risk factors for survival of osteosarcoma | (124) |
| NLR | 2162 | – | Patients with osteosarcoma | Meta-analysis | OS/DPS | High levels of NLR as risk factors for survival of osteosarcoma | (125) |
| Pretreatment NLR | 172 | Turkey | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS | High levels of NLR as risk factors for survival of osteosarcoma | (126) |
| Pretreatment NLR | 162 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS | High levels of NLR as risk factors for survival of osteosarcoma | (127) |
| NLR at the first cycle of chemotherapy | 96 | China | Patients who underwent NACT for osteosarcoma | Multi-center retrospective study | pCR | High levels of NLR as risk factors for the effect of NACT | (128) |
| NLR at the first cycle of chemotherapy | 186 | Iran | Patients who underwent NACT for osteosarcoma | Multi-center prospective study | OS/DFS | High levels of NLR as risk factors for survival of osteosarcoma | (129) |
| NLR during chemotherapy | 164 | France | Patients with osteosarcoma and treated with M-EI chemotherapy | Multi-center prospective study | OS/EFS | High levels of NLR at 4 weeks as risk factors for survival of osteosarcoma | (130) |
| NLR (baseline, during treatment, delta) | 251 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS | High levels of baseline NLR and delta NLR as risk factors for survival of osteosarcoma | (131) |
| Pretreatment SII | 126 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS | High levels of SII as risk factors for survival of osteosarcoma | (132) |
| Pretreatment SII | 86 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | EFS/CSS | High levels of SII as risk factors for survival of osteosarcoma | (133) |
| Pretreatment SII | 125 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS | High levels of SII as risk factors for survival of osteosarcoma | (134) |
| Pretreatment LIPI | 184 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | Metastasis | Low levels of LIPI as risk factors for metastasis of osteosarcoma | (135) |
| Pretreatment NPS | 133 | China | Pretreatment patients with osteosarcoma | Single-center retrospective study | OS/PFS | High levels of NPS as risk factors for survival of osteosarcoma | (136) |