Table 2.

Median change in laboratory parameters depending on generation of EGFR TKI administered

	1st/2nd Gen	3rd Gen	p-value
Median ∆NLR (n)
At 6 weeks	− 0.80 (35)	− 0.80 (60)	0.934
At 3 months	− 0.20 (38)	− 1.00 (62)	0.701
At 6 months	− 0.85 (26)	− 0.90 (51)	0.934
At 12 months	− 0.55 (16)	− 0.70 (38)	0.870
Median ∆PLR (n)
At 6 weeks	− 16.40 (35)	− 5.05 (60)	0.803
At 3 months	− 0.75 (38)	− 11.30 (62)	0.931
At 6 months	− 25.05 (26)	− 24.60 (51)	0.526
At 12 months	− 23.80 (16)	− 25.20 (38)	0.754
Median ∆ANC (n)
At 6 weeks	− 1.21 (35)	− 1.54 (60)	0.144
At 3 months	− 0.51 (38)	− 1.67 (62)	0.026*
At 6 months	− 1.48 (26)	− 2.61 (51)	0.093
At 12 months	− 0.65 (16)	− 1.22 (38)	0.061
Median ∆ALC (n)
At 6 weeks	− 0.07 (35)	− 0.20 (60)	0.048*
At 3 months	0.00 (38)	− 0.22 (62)	0.058
At 6 months	0.10 (26)	− 0.16 (51)	0.077
At 12 months	0.03 (16)	− 0.26 (38)	0.191
Median ∆Platelets (n)
At 6 weeks	− 26.0 (35)	− 60.0 (61)	0.004**
At 3 months	− 14.5 (38)	− 55.0 (64)	0.010*
At 6 months	− 49.0 (27)	− 75.0 (55)	0.274
At 12 months	− 31.0 (16)	− 55.0 (39)	0.252

Statistical significance assessed with Mann–Whitney tests (α = 0.05); *p < 0.05, **p < 0.005