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. 2024 May 16;19(8):2293–2307. doi: 10.1007/s11739-024-03626-3

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© The Author(s) 2024

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Fig. 2 — FHRs PLS-DA classification model: a high (H-FHRs > 40%, blue) vs low (L-FHRs < 40%, green) score plot, axes represent the latent components, the amount of explained variance were reported in bracket. b Metabolites showing a VIP score > 1.5 in the PLS‐DA analysis. c Volcano plot reporting metabolite concentration fold changes and their statistical significance comparing H-FHRs vs L-FHRs subjects. d Metabolite set enrichment analysis using the selected metabolites (VIP and Volcano) (Color figure online)