Fig. 5.

Conformation changes induced by BLG variants assessed through PCA. (A) Root Mean Square Inner Products (RMSIPs) of the first ten PCs show similarities and differences between the conformational spaces of the WT and variants. (B) Projection of first two PCs for all the systems. Black, red, purple, green, and blue colors represent the WT, G17A, W19C, F136S, and C119R systems of BLG, respectively. (C) Structural changes in all the systems with respect to PC1 are represented using extreme conformations with 30 frames. Black-dashed circles represent large conformational changes, and red arrows represent the size and direction of movements. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)