Fig. 5.

Combination therapy eliminates advanced-stage murine melanoma and hepatocellular carcinoma. a Therapeutic schedule for advanced-stage murine melanoma treatment (n = 7–8 biologically independent animals). b Tumor volume monitoring and statistical analysis for B16-luci tumor model. c Photographs of the harvest tumors at the monitoring end timepoint, scale bar = 1 cm. A dotted circle indicates a single mouse in which the tumor was eradicated. Toxicity monitoring of mice in different treatment groups for body weight in d, body temperature in e, and toxicity score in (f). g Therapeutic schedule for advanced-stage murine hepatocellular carcinoma treatment (n = 8 biologically independent animals). h Tumor volume monitoring and statistical analysis of tumors for different treatment groups. i Representative tumor-bearing mice post-treatment. j Mice survival curve monitoring for different treatment groups. k Body weight monitoring for different treatment groups. Data are shown as mean ± s.d. P values of final tumor volume were determined by one-way ANOVA with a Tukey post hoc test. The survival statistical significance was analyzed by log-rank (Mantel–Cox) test