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. Author manuscript; available in PMC: 2024 Nov 22.
Published in final edited form as: Placenta. 2016 May 30;44:23–33. doi: 10.1016/j.placenta.2016.05.010

Table 2.

Transcripts differentially expressed between IAI and iPTB VT specimens by RNA-Seq.

Long RNA Transcripts
Gene Symbol Linear Fold Change Description Raw p value† FDR†
MPO 3.13 myeloperoxidase <0.001 <0.001
ACTA1 3.04 actin, alpha 1, skeletal muscle <0.001 <0.001
S100A12 2.99 S100 calcium binding protein A12 <0.001 <0.001
PRTN3 2.79 proteinase 3 (myeloblastin) <0.001 0.002
S100A8 2.62 S100 calcium binding protein A8 <0.001 <0.001
SPSB4 2.62 splA/ryanodine receptor domain and SOCS box containing 4 <0.001 0.004
MCEMP1 2.37 chromosome 19 open reading frame 59 (mast cell-expressed membrane protein 1) <0.001 0.023
SCG2 2.36 secretogranin II <0.001 0.003
ST6GALNAC5 2.35 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 <0.001 0.022
RRM2 2.32 ribonucleotide reductase M2 <0.001 0.002
ALPL 2.31 alkaline phosphatase, liver/bone/kidney <0.001 0.015
FUT9 2.31 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) <0.001 0.005
SDS 2.28 serine dehydratase <0.001 0.028
FFAR2 2.27 free fatty acid receptor 2 <0.001 0.028
HK3 2.23 hexokinase 3 (white cell) <0.001 0.017
HIST1H2BM 2.22 histone cluster 1, H2bm <0.001 0.010
ANK1 2.21 ankyrin 1, erythrocytic <0.001 0.003
RP1 2.19 retinitis pigmentosa 1 (autosomal dominant) <0.001 0.023
SBSPON 2.14 somatomedin B and thrombospondin, type 1 domain containing <0.001 0.005
CNN1 2.13 calponin 1, basic, smooth muscle <0.001 0.014
MMP25 2.12 matrix metallopeptidase 25 <0.001 0.028
S1PR5 2.12 sphingosine-1-phosphate receptor 5 <0.001 0.053
MASP1 2.11 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) <0.001 0.004
HPGDS 2.10 hematopoietic prostaglandin D synthase <0.001 0.005
HIST1H4A 2.07 histone cluster 1, H4e <0.001 0.007
C17orf51 2.07 chromosome 17 open reading frame 51 <0.001 0.026
HIST1H2BL 2.05 histone cluster 1, H2bl <0.001 0.029
SLC17A9 2.04 solute carrier family 17 (vesicular nucleotide transporter), member 9 <0.001 0.028
MMP9 2.04 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) <0.001 0.069
SAPCD2 2.03 suppressor APC domain containing 2 <0.001 0.067
HIST1H4L 2.03 histone cluster 1, H4e <0.001 0.028
HIST1H2AJ 2.03 histone cluster 1, H2aj <0.001 0.017
NETO2 2.02 neuropilin (NRP) and tolloid (TLL)-like 2 <0.001 0.035
HIST1H2BB 2.00 histone cluster 1, H2bb <0.001 0.029
DDIAS 2.00 DNA damage-induced apoptosis suppressor, nitric oxide-inducible <0.001 0.068
AMICA1 1.99 adhesion molecule, interacts with CXADR antigen 1 <0.001 0.026
CLSPN 1.99 claspin <0.001 0.028
HIST1H1B 1.97 histone cluster 1, H1b <0.001 0.004
ANKRD65 1.97 ankyrin repeat domain 65 <0.001 0.033
CD180 1.96 CD180 molecule <0.001 0.039
UBE2C 1.95 ubiquitin-conjugating enzyme E2C <0.001 0.033
KLHL6 1.94 kelch-like family member 6 <0.001 0.009
HIST1H2AB 1.93 histone cluster 1, H2ab <0.001 0.050
HIST1H3H 1.93 histone cluster 1, H3a <0.001 0.023
HIST1H3I 1.90 histone cluster 1, H3a <0.001 0.036
C3orf58 1.89 chromosome 3 open reading frame 58 <0.001 0.014
PANK1 1.89 pantothenate kinase 1 <0.001 0.018
HIST1H3F 1.88 histone cluster 1, H3a <0.001 0.018
IL33 1.88 interleukin 33 <0.001 0.020
PDLIM3 1.87 PDZ and LIM domain 3 <0.001 0.025
KCNJ5 1.86 potassium inwardly-rectifying channel, subfamily J, member 5 <0.001 0.032
NNAT 1.86 neuronatin <0.001 0.014
HIST1H3B 1.85 histone cluster 1, H3a <0.001 0.026
FAS 1.85 Fas cell surface death receptor <0.001 0.036
PHGDH 1.84 phosphoglycerate dehydrogenase <0.001 0.039
HIST1H3J 1.83 histone cluster 1, H3a <0.001 0.047
LY96 1.83 lymphocyte antigen 96 <0.001 0.071
RAB23 1.82 RAB23, member RAS oncogene family <0.001 <0.001
CDC20 1.82 cell division cycle 20 <0.001 0.081
BAG2 1.80 BCL2-associated athanogene 2 <0.001 0.009
RAC2 1.80 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.001 0.090
SERPINA1 1.80 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 <0.001 0.055
HIST1H2BJ 1.78 histone cluster 1, H2bj <0.001 0.049
ROBO1 1.77 roundabout, axon guidance receptor, homolog 1 (Drosophila) <0.001 0.028
SORL1 1.77 sortilin-related receptor, L(DLR class) A repeats containing <0.001 0.028
PRC1 1.76 protein regulator of cytokinesis 1 <0.001 0.026
IGSF6 1.76 immunoglobulin superfamily, member 6 <0.001 0.067
MGP 1.75 matrix Gla protein <0.001 0.007
LYZ 1.74 lysozyme <0.001 0.039
KCNE3 1.74 potassium voltage-gated channel, Isk-related family, member 3 <0.001 0.033
NUSAP1 1.74 nucleolar and spindle associated protein 1 <0.001 0.042
TRIB3 1.73 tribbles pseudokinase 3 <0.001 0.074
EMILIN1 1.73 elastin microfibril interfacer 1 <0.001 0.029
PRR11 1.71 proline rich 11 0.001 0.099
HIST1H2AG 1.71 histone cluster 1, H2ai <0.001 0.046
DOCK10 1.70 dedicator of cytokinesis 10 <0.001 0.057
BTK 1.70 Bruton agammaglobulinemia tyrosine kinase 0.001 0.093
HAVCR2 1.70 hepatitis A virus cellular receptor 2 <0.001 0.059
ARHGAP28 1.68 Rho GTPase activating protein 28 <0.001 0.023
FLNC 1.67 filamin C, gamma <0.001 0.026
SPEG 1.66 SPEG complex locus <0.001 0.069
PLOD2 1.62 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 <0.001 0.014
CTSS 1.62 cathepsin S <0.001 0.041
LBR 1.61 lamin B receptor <0.001 0.025
DOCK2 1.60 dedicator of cytokinesis 2 <0.001 0.064
PDE4B 1.59 phosphodiesterase 4B, cAMP-specific <0.001 0.072
CNTLN 1.54 centlein, centrosomal protein 0.001 0.098
HIST1H4H 1.49 histone cluster 1, H4e 0.001 0.088
GNE −1.50 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.001 0.092
WWC3 −1.50 WWC family member 3 0.001 0.098
CAPN6 −1.50 calpain 6 <0.001 0.068
TPTEP1 −1.51 transmembrane phosphatase with tensin homology pseudogene 1 0.001 0.092
EFNB1 −1.52 ephrin-B1 <0.001 0.073
MC1R −1.54 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) <0.001 0.072
COASY −1.55 CoA synthase <0.001 0.036
ULK4 −1.57 unc-51 like kinase 4 <0.001 0.018
PVRL1 −1.57 poliovirus receptor-related 1 (herpesvirus entry mediator C) <0.001 0.065
RAPGEF3 −1.58 Rap guanine nucleotide exchange factor (GEF) 3 <0.001 0.039
TMEM184A −1.58 transmembrane protein 184A <0.001 0.064
EMP2 −1.60 epithelial membrane protein 2 <0.001 0.030
GLIS2 −1.60 GLIS family zinc finger 2 <0.001 0.015
KALRN −1.62 kalirin, RhoGEF kinase <0.001 0.074
EFHD1 −1.62 EF-hand domain family, member D1 <0.001 0.053
PACSIN3 −1.63 protein kinase C and casein kinase substrate in neurons 3 <0.001 0.028
TMEM108 −1.67 transmembrane protein 108 <0.001 0.047
CITED4 −1.69 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 <0.001 0.068
PGAP3 −1.69 post-GPI attachment to proteins 3 <0.001 0.016
CCDC113 −1.71 coiled-coil domain containing 113 <0.001 0.059
STX1B −1.75 syntaxin 1B 0.001 0.094
FAM109A −1.76 family with sequence similarity 109, member A <0.001 0.026
CORO6 −1.85 coronin 6 <0.001 0.033
ALPP −1.86 alkaline phosphatase, placental <0.001 0.016
LOC100129345 −1.88 uncharacterized LOC100129345 <0.001 0.019
PNMT −1.97 phenylethanolamine N-methyltransferase <0.001 0.028
PRX −2.04 periaxin <0.001 0.003
AKNAD1 −2.05 AKNA domain containing 1 <0.001 0.001
CDH4 −2.07 cadherin 4, type 1, R-cadherin (retinal) <0.001 0.055
CYP1B1 −2.07 cytochrome P450, family 1, subfamily B, polypeptide 1 <0.001 0.023
LOC100996634 −2.12 transmembrane protein FLJ37396 <0.001 <0.001
CCDC162P −2.20 coiled-coil domain containing 162, pseudogene <0.001 0.001
L1CAM −2.24 L1 cell adhesion molecule <0.001 0.023
ADH1B −2.24 alcohol dehydrogenase 1B (class I), beta polypeptide <0.001 0.023
DNASE1L3 −2.32 deoxyribonuclease I-like 3 <0.001 0.015
ALPPL2 −2.40 alkaline phosphatase, placental-like 2 <0.001 <0.001
ATP1A2 −2.47 ATPase, Na+/K+ transporting, alpha 2 polypeptide <0.001 0.003
MUC19 −2.48 mucin 19, oligomeric <0.001 0.003
LDB3 −2.54 LIM domain binding 3 <0.001 0.001
ATP8A2 −2.66 ATPase, aminophospholipid transporter, class I, type 8A, member 2 <0.001 0.002
Mature miRNA Transcripts
miRNA Linear Fold Change miRBase Accession No. Raw p value† FDR†
miR-887–3p 2.35 MIMAT0004951 <0.001 0.036
miR-154–5p 1.65 MIMAT0000452 <0.001 0.067
miR-376b-5p 1.59 MIMAT0022923 <0.001 0.067
miR-376c-3p 1.58 MIMAT0000720 <0.001 0.036
miR-500a-5p 1.57 MIMAT0004773 <0.001 0.062
miR-133a-3p 1.40 MIMAT0000427 <0.001 0.036
miR-223–3p 1.20 MIMAT0000280 <0.001 0.036
†

Only the raw p values and FDRs from the ‘edgeR’ analysis are shown; all transcripts were additionally found to be statistically significant based on ‘DESeq2’ analysis. FDR=false discovery rate.