Table 1.
Characteristics of individual studies on TOLLIP variants included in the meta-analysis of susceptibility to ILD
| References | Year | Country | Ethnicity | Disease | Numbers | Minor alleles (%) | Allele association | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Case | Control | OR | 95% CI | p value | ||||||
| rs5743890 | ||||||||||||
| Patrícia Caetano Mota25 | 2022 | Portuguese | European | IPF | 64 | 74 | 14.80 | 18.20 | 0.78 | 0.41 | 1.48 | 0.45 |
| Javier Guzmán-Vargas14 | 2021 | Mexico | European | IPF | 93 | 174 | 0.00 | 41.52 | 0.01 | 0.00 | 0.10 | 0.00 |
| Jonsson, E. 15 | 2021 | Sweden | European | RA-ILD | 60 | 2350 | 20.00 | 19.42 | 1.04 | 0.63 | 1.70 | 0.01 |
| Francesco Bonella16 | 2021 | Germany | European | IPF | 62 | 50 | 11.29 | 11.00 | 1.03 | 0.45 | 2.38 | 0.95 |
| Brett Ley17 | 2017 | America | European | CHP/IPF | 442 | 503 | 15.27 | 14.20 | 1.09 | 0.84 | 1.4 | 0.51 |
| Imre Noth-118 | 2013 | America | European | IPF | 542 | 542 | 10.98 | 15.04 | 0.70 | 0.54 | 0.90 | 0.01 |
| Imre Noth-218 | 2013 | America | European | IPF | 544 | 687 | 9.00 | 14.99 | 0.56 | 0.43 | 0.72 | 0.00 |
| Imre Noth-3 18 | 2013 | America | European | IPF | 324 | 702 | 10.03 | 17.02 | 0.54 | 0.41 | 0.73 | 0.00 |
| In all | 2131 | 5082 | 11.42 | 18.92 | ||||||||
| rs111521887 | ||||||||||||
| Patrícia Caetano Mota25 | 2022 | Portuguese | European | IPF | 64 | 74 | 19.50 | 12.80 | 1.65 | 0.86 | 3.16 | 0.13 |
| Javier Guzmán-Vargas14 | 2021 | Mexico | European | IPF | 93 | 174 | 43.75 | 44.23 | 0.98 | 0.47 | 2.04 | 0.96 |
| Jonsson, E.15 | 2021 | Sweden | European | RA-ILD | 60 | 2350 | 33.33 | 19.55 | 2.06 | 1.4 | 3.03 | 0.00 |
| Imre Noth-118 | 2013 | America | European | IPF | 542 | 542 | 28.97 | 21.03 | 1.53 | 1.26 | 1.86 | 0.00 |
| Imre Noth-218 | 2013 | America | European | IPF | 544 | 687 | 25.00 | 17.98 | 1.52 | 1.25 | 1.85 | 0.00 |
| Imre Noth-318 | 2013 | America | European | IPF | 324 | 702 | 22.99 | 19.02 | 1.27 | 1.01 | 1.59 | 0.04 |
| In all | 1627 | 4529 | 28.92 | 22.44 | ||||||||
| rs3750920 | ||||||||||||
| Patrícia Caetano Mota25 | 2022 | Portuguese | European | IPF | 64 | 74 | 50.00 | 41.20 | 1.43 | 0.89 | 2.3 | 0.14 |
| Francesco Bonella16 | 2021 | Germany | European | IPF | 62 | 50 | 45.97 | 46.00 | 1.00 | 0.59 | 1.69 | 1.00 |
| Fingerlin, T. E.19 | 2013 | America | European | IIP | 1615 | 4683 | 50.19 | 43.80 | 1.29 | 1.19 | 1.40 | 0.00 |
| Imre Noth-118 | 2013 | America | European | IPF | 542 | 542 | 29.15 | 21.03 | 1.54 | 1.27 | 1.88 | 0.00 |
| Imre Noth-218 | 2013 | America | European | IPF | 544 | 687 | 25.00 | 17.98 | 1.52 | 1.25 | 1.85 | 0.00 |
| In all | 2827 | 6036 | 40.06 | 34.00 | ||||||||
OR: odds ratio; CI: confidence interval; IPF: idiopathic pulmonary fibrosis; RA: rheumatoid arthritis; ILD: interstitial lung diseases; IIP: idiopathic interstitial pneumonia; CTD-ILD: connective tissue disease associated interstitial lung diseases; IPAF: Interstitial pneumonitis with autoimmune features; CHP: chronic hypersensitivity pneumonitis