Table 2.
Analysis of the association between the TOLLIP variants and susceptibility to ILD
| Variants | Population | No. of studies | No. of alleles | Test of association | Test of heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR | 95%CI | p value | Model | p value | I2 | |||
| rs5743890, C | Overall | 8 | 4170 | 10,147 | 0.72 | 0.53-0.99 | 0.04 | RE | <0.0000 | 80% |
| IPF | 6 | 3186 | 4440 | 0.62 | 0.44-0.86 | 0.004 | RE | 0.004 | 71% | |
| rs111521887, G | Overall | 6 | 3100 | 9022 | 1.48 | 1.33-1.65 | <0.0000 | FE | 0.3 | 17% |
| rs3750920, T | Overall | 5 | 5654 | 12,072 | 1.34 | 1.26-1.44 | <0.0000 | FE | 0.23 | 29% |
OR: odds ratio; CI: confidence interval; RE: R random effects model; FE: F fixed effects model