Table 4.
Analysis of the association between the TOLLIP polymorphisms and survival of patients with ILD
| Variants | Population | No. of studies | Test of association | Test of heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p value | Model | p value | I2 | |||
| Associations with survival | ||||||||
| rs5743890 | Overall | 6 | 1.10 | 0.77-1.57 | 0.59 | RE | 0.04 | 56% |
| IPF | 2 | 1.59 | 1.07-2.36 | 0.02 | FE | 0.21 | 38% | |
| rs3750920 | Overall | 2 | 0.91 | 0.61-1.36 | 0.64 | FE | 0.67 | 0% |
| rs111521887 | IPF | 1 | 1.87 | 0.97-3.59 | 0.06 | FE | 0.25 | 24% |
| Associations with transplant-free survival | ||||||||
| rs5743890 | Overall | 5 | 1.14 | 0.90-1.46 | 0.27 | FE | 0.13 | 44% |
HR, hazard ratio; CI, confidence interval; RE, R random effects model; FE, F fixed effects model