Fig. 6.

Exploring the Mechanisms of MST1 in Alzheimer's Disease through RNA-seq. The analysis of differentially expressed genes (DEGs) between 5xFAD + AAV-vehicle group and 5xFAD + AAV-shMST1 group. A Hierarchical clustering heatmap analysis of DEGs in each sample. The intensity of color represents the level of differentially expressed genes. Red indicates relatively high expression and blue represents relatively low expression. C1, C2, and C3 represent three samples of the 5xFAD + AAV-vehicle, M1, M2, and M3 represent three samples of the 5xFAD + AAV-shMST1. B Venn diagram of DEGs for two datasets. A total of 23776 co-expression genes were obtained. C Sankey diagram showing KEGG pathways enriched by DEGs. D GSEA plot of the Oxidative phosphorylation pathway. p < 0.05, p-adjust < 0.05. E GSEA plot of the PI3K-Akt pathway p < 0.05, p-adjust < 0.05