Physiochemical and medicinal properties of synthesized hybrids 20(a–j).
| Compound | Molecular weight | nHA | nHD | Log P | TPSA log | nRot | Synthetic accessibility score | Lipinski's rule |
|---|---|---|---|---|---|---|---|---|
| 20a | 532.19 | 6 | 1 | 6.275 | 72.95 | 10.0 | 2.0 | Rejected |
| 20b | 504.16 | 6 | 1 | 4.573 | 72.95 | 7.0 | 2.0 | Accepted |
| 20c | 428.13 | 6 | 1 | 3.384 | 72.95 | 7.0 | 2.0 | Accepted |
| 20d | 536.15 | 8 | 1 | 4.386 | 91.41 | 9.0 | 2.0 | Accepted |
| 20e | 490.15 | 6 | 1 | 4.599 | 72.95 | 7.0 | 2.0 | Accepted |
| 20f | 510.09 | 6 | 1 | 4.552 | 72.95 | 7.0 | 2.0 | Accepted |
| 20g | 506.14 | 7 | 1 | 4.256 | 82.18 | 8.0 | 2.0 | Accepted |
| 20h | 494.12 | 6 | 1 | 4.412 | 72.95 | 7.0 | 2.0 | Accepted |
| 20i | 470.14 | 7 | 0 | 2.688 | 73.39 | 6.0 | 2.0 | Accepted |
| 20j | 456.16 | 6 | 0 | 3.805 | 64.16 | 8.0 | 2.0 | Accepted |