Absorption and distribution properties of synthesized hybrids 20(a–j).

Compound	Caco-2 permeability	HIA	BBB	PPB	MDCK-permeability	Pgp-inhibitor	Pgp-substrate	VDss
20a	−4.972	0.015	0.512	99.367	−4.614	0.971	0.0	0.629
20b	−5.031	0.0	0.884	97.656	−4.63	0.992	0.0	0.374
20c	−5.111	0.003	0.386	96.617	−4.691	0.324	0.188	−0.378
20d	−4.93	0.02	0.2	98.131	−4.542	0.943	0.0	0.325
20e	−5.077	0.001	0.767	97.504	−4.63	0.97	0.0	0.319
20f	−5.074	0.0	0.87	97.45	−4.696	0.868	0.0	0.368
20g	−5.027	0.002	0.716	97.504	−4.62	0.949	0.0	0.196
20h	−5.038	0.001	0.943	97.361	−4.567	0.984	0.0	0.267
20i	−5.065	0.002	0.346	93.793	−4.659	0.446	0.0	2.858
20j	−4.777	0.0	0.983	94.552	−4.668	0.476	0.039	−0.241