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(a) Strategy for site-specific synthesis of ac4C RNA. Retention of ac4C requires a solid support and protected building blocks that are labile to non-nucleophilic conditions (center), thus avoiding nucleophilic deprotection which cleaves ac4C (right). (b) Model substrates used in ac4C-DBU compatibility studies. (c) HPLC traces of model ceoc-C (top) and ac4C (bottom) substrates following exposure to DBU for 0.4 or 4 h. Extended HPLC traces are provided in the Supporting Information.
