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. 2024 Nov 22;19:164. doi: 10.1186/s13020-024-01035-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — GAS treatment attenuated the increased expression of KLK8 in the diabetic myocardium. A Immunohistochemical staining and quantification of elevated levels of KLK8 in the myocardium. B Immunoblot of KLK8 in the heart. C The level of expression of KLK8 mRNA in the heart. D Chemical structural formula of GAS. E-F. Molecular docking data of GAS with the KLK8 protein was analyzed using the automated docking software. E Two-dimensional interaction. F Three-dimensional interaction. G Cellular thermal transfer assay (CETSA) and immunoblotting analysis were performed with cells treated with 5 µM GAS and DMSO at different temperatures. The data are expressed as the mean ± SEM of three or more independent experiments; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.