FIGURE 8.

Schematic representation of the events underlying the effect of BD on iBAT mitochondrial functionality. BD treatment stimulates BAT mitochondrial respiration by improving the activity of the respiratory chain and UCP1. Increases in specific subunits of the five respiratory complexes and UCP1 underlie the BD effect on mitochondrial respiration. BD also increases the levels of proteins involved in the anaplerotic pathway that forms succinyl‐CoA from propionyl‐CoA. Succinyl‐CoA is the precursor of succinate, the substrate of complex II of the respiratory chain, and BD enhances the use of succinate as a respiratory substrate. The symbol +, when under parentheses, indicates that one or more subunits of the specific respiratory complexes or other indicated proteins were upregulated by the BD treatment.