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. 2024 Nov 22;10(47):eadr9891. doi: 10.1126/sciadv.adr9891

Fig. 4. Corticosubthalamic connectivity patterns of FUS-STN lesions.

Fig. 4.

Sign-response tractography for bradykinesia (A), rigidity (B), and tremor (C). From left to right: efficacy clusters, color-coded fiber distribution from each sweet spot, and track density maps (number of tracts per vertex), overlaid on the MNI surface template (28). The streamline distribution seeding from lesion volumes across patients is reconstructed in white. (D) ACD values based on FUS-STN connectivity with cortical regions of interest: M1, primary motor cortex; PMd, dorsal premotor cortex; PMv, ventral premotor cortex; SMA, supplementary motor area; pre-SMA, pre-supplementary motor area; and S1, primary somatosensory cortex. Color codes are consistently related to improvement in motor features: bradykinesia (blue), rigidity (green), and tremor (red).