Table 1. Characteristics of children with septic shock and respiratory failure who survived to hospital discharge.
| Characteristics | Oxygenation failure absent ( n = 122) |
Mild oxygenation failure ( n = 61) | Moderate oxygenation failure ( n = 58) | Severe oxygenation failure ( n = 50) |
|---|---|---|---|---|
| Sex, n (%) | ||||
| Male | 63 (52) | 32 (52) | 37 (64) | 28 (56) |
| Female | 59 (48) | 29 (48) | 21 (36) | 22 (44) |
| Age in years, median (IQR) | 6.7 (2.5–13.3) | 4.4 (1.4–11.5) | 4.6 (1.2–11.8) | 7.2 (1.6–12.4) |
| Race/Ethnicity | ||||
| American Indian/Alaskan Native | 4 (3%) | 2 (3%) | 2 (3%) | 0 (0%) |
| Asian | 7 (6%) | 2 (3%) | 3 (5%) | 3 (6%) |
| Black or African-American | 29 (24%) | 6 (10%) | 10 (17%) | 14 (28%) |
| White | 73 (60%) | 48 (79%) | 40 (69%) | 32 (64%) |
| Native Hawaiian or Other Pacific Islander | 2 (2%) | 0 (0%) | 0 (0%) | 1 (2%) |
| Unknown/Not reported | 10 (8%) | 6 (9%) | 4 (7%) | 2 (4%) |
| Baseline HRQL measure, median (IQR) | ||||
| PedsQL ( n = 180) | 82.6 (68.8–94.0) | 79.7 (63.0–90.7) | 82.7 (72.8–92.3) | 80.6 (68.8–97.2) |
| FS II-R ( n = 111) | 67.6 (60.7–85.7) | 64.3 (53.6–85.7) | 64.3 (57.1–78.6) | 75.0 (60.7–85.7) |
| Baseline FSS, median (IQR) | 7 (6–12) | 7 (6–11) | 6 (6–8) | 6 (7–13) |
| Arterial lactate (mmol/L), median (IQR) | ||||
| Day of PICU admission ( n = 155) | 3.2 (2–5.1) | 1.6 (1.1–3.1) | 2.3 (1.4–4.1) | 3.1 (1.6–5.5) |
| Highest value ( n = 233) | 3.2 (2–5.3) | 2.2 (1.4–3.4) | 2.6 (1.8–4.4) | 3.1 (2.3–7.6) |
| Vasoactive-inotropic score, median (IQR) | ||||
| Day of PICU admission ( n = 283) | 5 (0–12) | 2 (0–12) | 2.5 (0–10) | 4 (0–15) |
| Highest value | 10 (5–20) | 10 (5–18) | 10 (5–20) | 15 (8–28) |
| Medical history, n (%) | ||||
| Immunocompromised | 22 (18) | 4 (7) | 6 (10) | 9 (18) |
| Congenital immunodeficiency | 3 (6) | 0 (0) | 0 (0) | 1 (4) |
| Bone marrow/SCT | 1 (2) | 0 (0) | 0 (0) | 0 (0) |
| Malignancy | 3 (6) | 0 (0) | 2 (8) | 4 (17) |
| Rheumatologic disease | 2 (4) | 0 (0) | 0 (0) | 1 (4) |
| Sickle cell disease | 2 (4) | 0 (0) | 0 (0) | 0 (0) |
| Medical complexity algorithm category | ||||
| No chronic comorbid conditions | 59 (48%) | 27 (44%) | 37 (63%) | 22 (44%) |
| Chronic comorbid conditions (noncomplex) | 4 (3%) | 5 (8%) | 4 (7%) | 4 (8%) |
| Chronic comorbid conditions (complex) | 59 (48%) | 28 (46%) | 17 (29%) | 24 (48%) |
| Baseline tracheostomy, n (%) | 12 (10) | 3 (3) | 3 (5) | 5 (10) |
| Adjunct respiratory support | ||||
| Neuromuscular blockade | 88 (72%) | 51 (84%) | 48 (83%) | 45 (90%) |
| Days of neuromuscular blockade | 1 (0–3) | 2 (1–3) | 3 (1–6) | 5 (2–7) |
| HFV | 6 (5%) | 2 (3%) | 3 (5%) | 11 (22%) |
| ECLS | 2 (2%) | 2 (3%) | 3 (5%) | 7 (14%) |
| Mechanical ventilation days, median (IQR) | 6 (4–10) | 7 (5–12) | 9.5 (6–15) | 16 (10–27) |
| PICU LOS (d), median (IQR) | 8 (5–12) | 8 (6–15) | 10 (8–14) | 17.5 (11–28) |
| Hospital LOS (d), median (IQR) | 15 (8–24) | 15 (10–23) | 16.5 (12–25) | 28 (16–44) |
Abbreviations: ECLS, extracorporeal life support or ventricular assist device; FS II-R, Functional Status II-Revised; FSS, Functional Status Scale; HFV, high frequency ventilation; HRQL, health-related quality of life; IQR, interquartile range; LOS, length of stay; PedsQL, Pediatric Quality of Life Inventory 4.0; PICU, pediatric intensive care unit.