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. 2024 Oct 15;5(11):1681–1696. doi: 10.1038/s43018-024-00840-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Phylogenetic trees from WES of two patients with metastatic cancer. The shared EGFR mutation is annotated on the tree. Numbers on branches are mutations that accumulated between two nodes. Numbers in parentheses are exonic mutations that are not in the FFPE context. These trees show a long trunk of shared mutations before branching into separate clones. Consistently, the pie charts are made up of mixtures of clones that are shared between tumors.