Extended Data Fig. 3. Germline mutations and patient 1 and 6 WES results.

a, IGV tracks for the patients harboring germline variants, showing the germline EGFR mutations in the normal samples as well as tumors. Patient 4 also shows EGFR G873E on same read as L858R in the tumor samples, indicating that the two mutations are in cis. b, Phylogenetic tree from patient 6, with a germline variant identified by WES. c, Phylogenetic tree from patient 1 predicted to be independent by WES.