Table 1.
Demographic and clinical characteristics of the patients
| Patient | Age decade (gender)a | Smoking | Genetic ancestry | Stage | No. of tumors | Contralateral/Multilobar | Classification |
|---|---|---|---|---|---|---|---|
| III-1 | 50s (M) | Moderate | European | 0 | >13 | Y/Y | Germline |
| III-4 | 60s (F) | Never | European | 0 | 10 | Y/Y | Germline |
| 1 | 60s (F) | Former | European | IA | 4 | N/Y | Independentc |
| 2 | 80s (M) | Former | European | IA | 3b | N/N | Metastatic |
| 3 | 50s (F) | Never | African | IA | >3 | N/Y | Metastatic |
| 4 | 50s (F) | Former | Asian | IA | >5 | Y/Y | Germline |
| 5 | 50s (F) | Never | African | IA | 5 | Y/Y | Germline |
| 6 | 70s (F) | Former | European | IIB | 4 | N/N | Germlinec |
| 7 | 70s (F) | Never | European | IB | 2 | N/Y | Mosaic |
| 8 | 80s (F) | Former | European | IA | 4 | Y/Y | Mosaic |
| 9 | 60s (F) | Never | European | I | 4 | Y/Y | Mosaic |
| 10 | 70s (F) | Former | European | IA | 4 | Y/Y | Mosaic |
aSelf-reported gender.
bAdditional tumors observed on pathological assessment.
cSolely inferred from WES.
Clinical characteristics of two patients from a familial lung cancer pedigree (III-1 and III-4) and ten patients with sporadic multiple primary lung cancers. The stage refers to the clinical impression at the time of surgical resection following the International Association of Small Cell Lung Cancer, 8th edn staging guidelines. The number of tumors corresponds to those observed on CT scans throughout the patient’s lifetime. F, Female; M, Male; N, No; Y, Yes.