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. 2024 Oct 30;5(11):1713–1736. doi: 10.1038/s43018-024-00773-6

Fig. 4. Chromatin accessibility evidence for subtype-specific cell of origin.

Fig. 4

a, Monocle pseudotime plots of tumor and benign breast duct cells from three representative basal-like BC samples. b, Monocle pseudotime plots of tumor and benign breast duct cells from three representative luminal BC samples. c, Correlation matrices for TF motif scores from tumor cells and benign duct cells for the BC samples in a. d, Correlation matrices for TF motif scores from tumor cells and benign duct cells for the BC samples in b. e, Heatmap of motif scores for the top 15 differentially accessible motifs identified in LM, LP and BP cells. Scores are shown for tumor cells from each basal-like snATAC-seq sample and for benign breast duct cells. f, Heatmap of motif scores for the top 15 differentially accessible motifs identified in LM, LP and BP cells. Scores are shown for tumor cells from each luminal snATAC-seq sample and for benign breast duct cells.