Table 2.
Inhibition profile of AMP-ester isosteres
| # | Compound |
CnAcs1 |
CnKbc1 |
LiAcs1 |
|||
|---|---|---|---|---|---|---|---|
| IC50 (μM) | 95% CI [LL, UL] | IC50 (μM) | 95% CI [LL, UL] | IC50 (μM) | 95% CI [LL, UL] | ||
| i | Methyl-AMP | >100 | >100 | 69.9 | [52.8, 98.9] | ||
| ii | Ethyl-AMP | 8.0 | [5.8, 11.1] | >100 | 2.0 | [1.4, 2.8] | |
| iii | Cyclopropyl-AMP | 8.7 | [7.5, 10.2] | >100 | 2.2 | [1.8, 2.7] | |
| iv | Propyl-AMP | 21.1 | [11.3, 48.0] | >100 | 13.5 | [10.7, 17.0] | |
| v | Isopropyl-AMP | 25.3 | [21.6, 29.6] | >100 | 6.7 | [5.5, 8.3] | |
| vi | Allyl-AMP | 41.0 | [30.0, 59.8] | >100 | 12.5 | [10.6, 14.8] | |
| vii | Propargyl-AMP | 55.1 | [48.8, 62.6] | >100 | 10.2 | [7.5, 13.9] | |
| viii | Butyl-AMP | >100 | 7.8 | [5.7, 10.8] | >100 | ||
| ix | Diethyl-AMP | >100 | >100 | >100 | |||
| x | Cyclopentyl-AMP | >100 | >100 | >100 | |||