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. 2024 Nov 22;14:29013. doi: 10.1038/s41598-024-79909-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Time-adjusted distribution of Log2-transformed SIM estimates across cohorts, evaluated with age and sex as covariates. Distribution of estimate for the SIM evaluated for each cohort per time. All the SIM measurements were log2 transformed. For each cohort, linear models were fitted for each SIM, where SIM expression was evaluated with age, sex, and time as covariates. Time was taken as a continuous covariate. A density plot estimate for time variable for each cohort was plotted.