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. 2024 Nov 22;14:29013. doi: 10.1038/s41598-024-79909-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Density plots of Log2-transformed SIM estimates at T1, T2, and T3 across HCV cohorts compared to SARS-CoV-2 Cohort 2 baseline. Distribution of estimate for SIM for each time point evaluated across cohorts, with SARS-CoV-2 cohort 2 as baseline cohort. All the SIM measurements were log2 transformed. For each of the three-time points evaluated (T1, T2, T3), linear models were fitted for each SIM, where SIM expression was evaluated with age, sex and cohort as covariates. Each HCV cohort for each time point was evaluated, with SARS-CoV-2 cohort 2 samples were taken as a baseline for comparison. A density plot estimate was plotted for each time point and for the three HCV cohorts evaluated against the SARS-CoV-2 cohort 2.