Table 5.
Results of genotoxicity – prediction of Ames test results for AP-238 using: Percepta, PreADMET, VEGA-Consensus, ADMETlab and OCHEM.
| Parameter | In silico method | ||||
|---|---|---|---|---|---|
| Percepta | PreADMET | VEGA - Consensus | ADMETlab | OChem | |
| Result | Probability of positive Ames test, 14.00% |
Mutagen TA100_10RLI: negative TA100_NA: negative TA1535_10RLI: negative TA1535_NA: negative |
Non-mutagenic | Non-mutagenic | Inactive |
| Reliability |
Borderline (RI = 0.46) |
NA | RI = 0.89 | NA | RI = 0.86 |
| Toxicophore |
|
NA | NA | NA | NA |
RI – Reliability Index; NA – Not Applicable.