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The titre of FVIII-specific IgG1–IgG4 during the ReITIrate study period for individual subjects (OD): (a) Subject that obtained a negative inhibitor titre at week 60; (b, c) Subjects deemed as partial success according to protocol definitions; (d) Subject who achieved complete ITI success.
The y-axis scale differs between subjects. *Subjects that completed ITI and the ReITIrate study.
FVIII, factor VIII; Ig, immunoglobulin; ITI, immune tolerance induction; OD, optical density.
