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Aggravated symptoms of psoriasis in imiquimod (IMQ)-induced mice treated with interleukin (IL)-36γ. Groups of mice were treated with Vaseline (A), IMQ (B), IMQ and IWR-1 (IMQ + IWR-1; C), IMQ and IL-36γ (IMQ + IL-36γ; D), or IMQ, IWR-1, and IL-36γ (IMQ + IWR-1 + IL-36γ; E). (F) Total psoriasis area and severity index (PASI) scores, including individual scales (0–4) for erythema, scaling, and thickness in each group. *P < 0.05
