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. 2024 Nov 22;22:729. doi: 10.1186/s12951-024-03015-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Therapeutic effects of RCMNs in alleviating lung inflammation and injury in mice. A Flow cytometry analysis of bronchoalveolar lavage fluid (BALF) reveals the population of alveolar macrophages (CD11c⁺SiglecF⁺), identified by gating on CD45⁺SiglecF⁺CD11c⁺ cells. B The proportion of classical monocytes (CD45⁺CD11b⁺ Ly6C^hi) in the blood was found to decrease following treatment with RCMNs (C) Flow cytometry analysis of blood neutrophils (CD45⁺CD11b⁺ Ly6G⁺) shows a decrease in neutrophil counts in ALI mice receiving RCMNs. D Survival curves demonstrate a significant improvement in the survival rate of mice challenged with a high dose of LPS (10 mg/kg) and subsequently treated with RCMNs compared to the PBS control group. E, F Quantification of interleukin-6 (IL-6) and tumor necrosis factor (TNF) levels in BAL fluid