Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1982 Jul 15;206(1):1–12. doi: 10.1042/bj2060001

Fructose 2,6-bisphosphate 2 years after its discovery.

H G Hers, E Van Schaftingen
PMCID: PMC1158542  PMID: 6289809

Full text

PDF
12

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avigad G. Stimulation of yeast phosphofructokinase activity by fructose 2,6-bisphosphate. Biochem Biophys Res Commun. 1981 Oct 15;102(3):985–991. doi: 10.1016/0006-291x(81)91635-1. [DOI] [PubMed] [Google Scholar]
  2. Brand I. A., Söling H. D. Rat liver phosphofructokinase. Purification and characterization of its reaction mechanism. J Biol Chem. 1974 Dec 25;249(24):7824–7831. [PubMed] [Google Scholar]
  3. Carnal N. W., Black C. C. Pyrophosphate-dependent 6-phosphofructokinase, a new glycolytic enzyme in pineapple leaves. Biochem Biophys Res Commun. 1979 Jan 15;86(1):20–26. doi: 10.1016/0006-291x(79)90376-0. [DOI] [PubMed] [Google Scholar]
  4. Castaño J. G., Nieto A., Felíu J. E. Inactivation of phosphofructokinase by glucagon in rat hepatocytes. J Biol Chem. 1979 Jul 10;254(13):5576–5579. [PubMed] [Google Scholar]
  5. Ciriacy M., Breitenbach I. Physiological effects of seven different blocks in glycolysis in Saccharomyces cerevisiae. J Bacteriol. 1979 Jul;139(1):152–160. doi: 10.1128/jb.139.1.152-160.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clarke S. D., Watkins P. A., Lane M. D. Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation. J Lipid Res. 1979 Nov;20(8):974–985. [PubMed] [Google Scholar]
  7. Claus T. H., Schlumpf J. R., el-Maghrabi M. R., Pilkis J., Pilkis S. J. Mechanism of action of glucagon on hepatocyte phosphofructokinase activity. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6501–6505. doi: 10.1073/pnas.77.11.6501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. De Wulf H., Hers H. G. The stimulation of glycogen synthesis and of glycogen synthetase in the liver by the administration of glucose. Eur J Biochem. 1967 Jul;2(1):50–56. doi: 10.1111/j.1432-1033.1967.tb00104.x. [DOI] [PubMed] [Google Scholar]
  9. El-Maghrabi M. R., Claus T. H., Pilkis J., Pilkis S. J. Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate. Biochem Biophys Res Commun. 1981 Aug 14;101(3):1071–1077. doi: 10.1016/0006-291x(81)91858-1. [DOI] [PubMed] [Google Scholar]
  10. Fletterick R. J., Madsen N. B. The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980;49:31–61. doi: 10.1146/annurev.bi.49.070180.000335. [DOI] [PubMed] [Google Scholar]
  11. Funayama S., Gancedo J. M., Gancedo C. Turnover of yeast fructose-bisphosphatase in different metabolic conditions. Eur J Biochem. 1980 Aug;109(1):61–66. doi: 10.1111/j.1432-1033.1980.tb04767.x. [DOI] [PubMed] [Google Scholar]
  12. Furuya E., Uyeda K. A novel enzyme catalyzes the synthesis of activation factor from ATP and D-fructose-6-P. J Biol Chem. 1981 Jul 25;256(14):7109–7112. [PubMed] [Google Scholar]
  13. Furuya E., Uyeda K. An activation factor of liver phosphofructokinase. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5861–5864. doi: 10.1073/pnas.77.10.5861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Furuya E., Uyeda K. Regulation of phosphofructokinase by a new mechanism. An activation factor binding to phosphorylated enzyme. J Biol Chem. 1980 Dec 25;255(24):11656–11659. [PubMed] [Google Scholar]
  15. Gancedo J. M., Gancedo C. Inactivation of gluconeogenic enzymes in glycolytic mutants of Saccharomyces cerevisiae. Eur J Biochem. 1979 Nov;101(2):455–460. doi: 10.1111/j.1432-1033.1979.tb19739.x. [DOI] [PubMed] [Google Scholar]
  16. Harris R. A. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate. Arch Biochem Biophys. 1975 Jul;169(1):168–180. doi: 10.1016/0003-9861(75)90330-6. [DOI] [PubMed] [Google Scholar]
  17. Hers H. G., Hue L., van Schaftingen E. The fructose 6-phosphate/fructose 1, 6 bisphosphate cycle. Curr Top Cell Regul. 1981;18:199–210. doi: 10.1016/b978-0-12-152818-8.50017-7. [DOI] [PubMed] [Google Scholar]
  18. Hers H. G. The control of glycogen metabolism in the liver. Annu Rev Biochem. 1976;45:167–189. doi: 10.1146/annurev.bi.45.070176.001123. [DOI] [PubMed] [Google Scholar]
  19. Hesbain-Frisque A. M., van Schaftingen E., Hers H. G. Structure and configuration of fructose 2,6-bisphosphate by 31P and 13C nuclear magnetic resonance. Eur J Biochem. 1981 Jul;117(2):325–327. doi: 10.1111/j.1432-1033.1981.tb06340.x. [DOI] [PubMed] [Google Scholar]
  20. Hue L., Blackmore P. F., Shikama H., Robinson-Steiner A., Exton J. H. Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs. J Biol Chem. 1982 Apr 25;257(8):4308–4313. [PubMed] [Google Scholar]
  21. Hue L., Hers H. G. On the use of (3H, 14C)labelled glucose in the study of the so-called "futile cycles" in liver and muscle. Biochem Biophys Res Commun. 1974 Jun 4;58(3):532–539. doi: 10.1016/s0006-291x(74)80453-5. [DOI] [PubMed] [Google Scholar]
  22. Hue L., Hers H. G. Utile and futile cycles in the liver. Biochem Biophys Res Commun. 1974 Jun 4;58(3):540–548. doi: 10.1016/s0006-291x(74)80454-7. [DOI] [PubMed] [Google Scholar]
  23. Hue L. The role of futile cycles in the regulation of carbohydrate metabolism in the liver. Adv Enzymol Relat Areas Mol Biol. 1981;52:247–331. doi: 10.1002/9780470122976.ch4. [DOI] [PubMed] [Google Scholar]
  24. Hue L., Van Schaftingen E., Blackmore P. F. Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin. Biochem J. 1981 Mar 15;194(3):1023–1026. doi: 10.1042/bj1941023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Jacob F. Evolution and tinkering. Science. 1977 Jun 10;196(4295):1161–1166. doi: 10.1126/science.860134. [DOI] [PubMed] [Google Scholar]
  26. Kagimoto T., Uyeda K. Hormone-stimulated phosphorylation of liver phosphofructokinase in vivo. J Biol Chem. 1979 Jul 10;254(13):5584–5587. [PubMed] [Google Scholar]
  27. Kagimoto T., Uyeda K. Regulation of rat liver phosphofructokinase by glucagon-induced phosphorylation. Arch Biochem Biophys. 1980 Sep;203(2):792–799. doi: 10.1016/0003-9861(80)90240-4. [DOI] [PubMed] [Google Scholar]
  28. Katz J., Rognstad R. Futile cycles in the metabolism of glucose. Curr Top Cell Regul. 1976;10:237–289. doi: 10.1016/b978-0-12-152810-2.50013-9. [DOI] [PubMed] [Google Scholar]
  29. Lane M. D., Mooney R. A. Tricarboxylic acid cycle intermediates and the control of fatty acid synthesis and ketogenesis. Curr Top Cell Regul. 1981;18:221–242. doi: 10.1016/b978-0-12-152818-8.50019-0. [DOI] [PubMed] [Google Scholar]
  30. Lederer B., Vissers S., Van Schaftingen E., Hers H. G. Fructose 2,6-bisphosphate in yeast. Biochem Biophys Res Commun. 1981 Dec 31;103(4):1281–1287. doi: 10.1016/0006-291x(81)90261-8. [DOI] [PubMed] [Google Scholar]
  31. MAKMAN R. S., SUTHERLAND E. W. ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI. J Biol Chem. 1965 Mar;240:1309–1314. [PubMed] [Google Scholar]
  32. Macy J. M., Ljungdahl L. G., Gottschalk G. Pathway of succinate and propionate formation in Bacteroides fragilis. J Bacteriol. 1978 Apr;134(1):84–91. doi: 10.1128/jb.134.1.84-91.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Malaisse W. J., Malaisse-Lagae F., Sener A. Glucose-induced accumulation of fructose-2,6-bisphosphate in pancreatic islets. Diabetes. 1982 Jan;31(1):90–93. doi: 10.2337/diab.31.1.90. [DOI] [PubMed] [Google Scholar]
  34. Malaisse W. J., Malaisse-Lagae F., Sener A. Presence of fructose-6-phosphate,2-kinase in pancreatic islets. FEBS Lett. 1981 Nov 30;135(1):203–206. doi: 10.1016/0014-5793(81)80977-5. [DOI] [PubMed] [Google Scholar]
  35. Malaisse W. J., Malaisse-Lagae F., Sener A., van Schaftingen E., Hers H. G. Is the glucose-induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofructokinase by fructose 2,6-bisphosphate? FEBS Lett. 1981 Mar 23;125(2):217–219. doi: 10.1016/0014-5793(81)80722-3. [DOI] [PubMed] [Google Scholar]
  36. Mörikofer-Zwez S., Stoecklin F. B., Walter P. Fructose 1,6-bisphosphatase in rat liver cytosol: activation after glucagon treatment in vivo and inhibition by fructose 2,6-bisphosphate in vitro. Biochem Biophys Res Commun. 1981 Jul 16;101(1):104–111. doi: 10.1016/s0006-291x(81)80016-2. [DOI] [PubMed] [Google Scholar]
  37. Müller D., Holzer H. Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation. Biochem Biophys Res Commun. 1981 Dec 15;103(3):926–933. doi: 10.1016/0006-291x(81)90899-8. [DOI] [PubMed] [Google Scholar]
  38. O'Brien W. E., Bowien S., Wood H. G. Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii. J Biol Chem. 1975 Nov 25;250(22):8690–8695. [PubMed] [Google Scholar]
  39. PASSONNEAU J. V., LOWRY O. H. Phosphofructokinase and the Pasteur effect. Biochem Biophys Res Commun. 1962 Feb 20;7:10–15. doi: 10.1016/0006-291x(62)90134-1. [DOI] [PubMed] [Google Scholar]
  40. PONTIS H. G., FISCHER C. L. SYNTHESIS OF D-FRUCTOPYRANOSE 2-PHOSPHATE AND D-FRUCTOFURANOSE 2-PHOSPHATE. Biochem J. 1963 Dec;89:452–459. doi: 10.1042/bj0890452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Pilkis S. J., El-Maghrabi M. R., McGrane M. M., Pilkis J., Claus T. H. The role of fructose 2,6-bisphosphate in regulation of fructose-1,6-bisphosphatase. J Biol Chem. 1981 Nov 25;256(22):11489–11495. [PubMed] [Google Scholar]
  42. Pilkis S. J., El-Maghrabi M. R., Pilkis J., Claus T. H., Cumming D. A. Fructose 2,6-bisphosphate. A new activator of phosphofructokinase. J Biol Chem. 1981 Apr 10;256(7):3171–3174. [PubMed] [Google Scholar]
  43. Pilkis S. J., El-Maghrabi M. R., Pilkis J., Claus T. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate. J Biol Chem. 1981 Apr 25;256(8):3619–3622. [PubMed] [Google Scholar]
  44. Pilkis S., Schlumpf J., Pilkis J., Claus T. H. Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes. Biochem Biophys Res Commun. 1979 Jun 13;88(3):960–967. doi: 10.1016/0006-291x(79)91501-8. [DOI] [PubMed] [Google Scholar]
  45. Reeves R. E., South D. J., Blytt H. J., Warren L. G. Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase. J Biol Chem. 1974 Dec 25;249(24):7737–7741. [PubMed] [Google Scholar]
  46. Richards C. S., Furuya E., Uyeda K. Regulation of fructose 2,6-P2 concentration in isolated hepatocytes. Biochem Biophys Res Commun. 1981 Jun;100(4):1673–1679. doi: 10.1016/0006-291x(81)90711-7. [DOI] [PubMed] [Google Scholar]
  47. Richards C. S., Uyeda K. Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon. Biochem Biophys Res Commun. 1980 Dec 31;97(4):1535–1540. doi: 10.1016/s0006-291x(80)80040-4. [DOI] [PubMed] [Google Scholar]
  48. SUTHERLAND E. W., RALL T. W. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem. 1958 Jun;232(2):1077–1091. [PubMed] [Google Scholar]
  49. Sabularse D. C., Anderson R. L. D-Fructose 2,6-bisphosphate: a naturally occurring activator for inorganic pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase in plants. Biochem Biophys Res Commun. 1981 Dec 15;103(3):848–855. doi: 10.1016/0006-291x(81)90888-3. [DOI] [PubMed] [Google Scholar]
  50. Sabularse D. C., Anderson R. L. Inorganic pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase in mung beans and its activation by D-fructose 1,6-bisphosphate and D-glucose 1, 6-bisphosphate. Biochem Biophys Res Commun. 1981 Jun;100(4):1423–1429. doi: 10.1016/0006-291x(81)90677-x. [DOI] [PubMed] [Google Scholar]
  51. Sawyer M. H., Baumann P., Baumann L. Pathways of D-fructose and D-glucose catabolism in marine species of Alcaligenes, Pseudomonas marina, and Alteromonas communis. Arch Microbiol. 1977 Mar 1;112(2):169–172. doi: 10.1007/BF00429331. [DOI] [PubMed] [Google Scholar]
  52. Stalmans W. The role of the liver in the homeostasis of blood glucose. Curr Top Cell Regul. 1976;11:51–97. doi: 10.1016/b978-0-12-152811-9.50009-2. [DOI] [PubMed] [Google Scholar]
  53. Söling H. D., Brand I. A. Covalent modification of phosphofructokinase by phosphorylation--dephosphorylation. Curr Top Cell Regul. 1981;20:107–138. [PubMed] [Google Scholar]
  54. Söling H. D., Kuduz J., Brand I. A. Inactivation of liver phosphofructokinase by phosphofructokinase phosphatase or by low pH is inhibited by fructose 2,6-bisphosphate. FEBS Lett. 1981 Aug 3;130(2):309–313. doi: 10.1016/0014-5793(81)81146-5. [DOI] [PubMed] [Google Scholar]
  55. Uyeda K., Furuya E., Luby L. J. The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases. J Biol Chem. 1981 Aug 25;256(16):8394–8399. [PubMed] [Google Scholar]
  56. Uyeda K., Furuya E., Sherry A. D. The structure of "activation factor" for phosphofructokinase. J Biol Chem. 1981 Aug 25;256(16):8679–8684. [PubMed] [Google Scholar]
  57. VINUELA E., SALAS M. L., SOLS A. End-product inhibition of yeast phosphofructokinase by ATP. Biochem Biophys Res Commun. 1963 Jul 18;12:140–145. doi: 10.1016/0006-291x(63)90250-x. [DOI] [PubMed] [Google Scholar]
  58. Van Schaftingen E., Hers H. G. Formation of fructose 2,6-bisphosphate from fructose 1,6-bisphosphate by intramolecular cyclisation followed by alkaline hydrolysis. Eur J Biochem. 1981 Jul;117(2):319–323. doi: 10.1111/j.1432-1033.1981.tb06339.x. [DOI] [PubMed] [Google Scholar]
  59. Van Schaftingen E., Hers H. G. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proc Natl Acad Sci U S A. 1981 May;78(5):2861–2863. doi: 10.1073/pnas.78.5.2861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Van Schaftingen E., Hers H. G. Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP. Biochem Biophys Res Commun. 1981 Aug 14;101(3):1078–1084. doi: 10.1016/0006-291x(81)91859-3. [DOI] [PubMed] [Google Scholar]
  61. Van Schaftingen E., Hers H. G. Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid. Biochem Biophys Res Commun. 1980 Oct 31;96(4):1524–1531. doi: 10.1016/0006-291x(80)91347-9. [DOI] [PubMed] [Google Scholar]
  62. Van Schaftingen E., Hue L., Hers H. G. Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase. Biochem J. 1980 Dec 15;192(3):887–895. doi: 10.1042/bj1920887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Van Schaftingen E., Hue L., Hers H. G. Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase. Biochem J. 1980 Dec 15;192(3):897–901. doi: 10.1042/bj1920897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Van Schaftingen E., Hue L., Hers H. G. Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo. Biochem J. 1980 Oct 15;192(1):263–271. doi: 10.1042/bj1920263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Van Schaftingen E., Jett M. F., Hue L., Hers H. G. Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3483–3486. doi: 10.1073/pnas.78.6.3483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. van Schaftingen E., Davies D. R., Hers H. G. Fructose-2,6-bisphosphatase from rat liver. Eur J Biochem. 1982 May;124(1):143–149. doi: 10.1111/j.1432-1033.1982.tb05917.x. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES