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. 1982 Jul 15;206(1):1–12. doi: 10.1042/bj2060001

Fructose 2,6-bisphosphate 2 years after its discovery.

H G Hers, E Van Schaftingen
PMCID: PMC1158542  PMID: 6289809

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Selected References

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  1. Avigad G. Stimulation of yeast phosphofructokinase activity by fructose 2,6-bisphosphate. Biochem Biophys Res Commun. 1981 Oct 15;102(3):985–991. doi: 10.1016/0006-291x(81)91635-1. [DOI] [PubMed] [Google Scholar]
  2. Brand I. A., Söling H. D. Rat liver phosphofructokinase. Purification and characterization of its reaction mechanism. J Biol Chem. 1974 Dec 25;249(24):7824–7831. [PubMed] [Google Scholar]
  3. Carnal N. W., Black C. C. Pyrophosphate-dependent 6-phosphofructokinase, a new glycolytic enzyme in pineapple leaves. Biochem Biophys Res Commun. 1979 Jan 15;86(1):20–26. doi: 10.1016/0006-291x(79)90376-0. [DOI] [PubMed] [Google Scholar]
  4. Castaño J. G., Nieto A., Felíu J. E. Inactivation of phosphofructokinase by glucagon in rat hepatocytes. J Biol Chem. 1979 Jul 10;254(13):5576–5579. [PubMed] [Google Scholar]
  5. Ciriacy M., Breitenbach I. Physiological effects of seven different blocks in glycolysis in Saccharomyces cerevisiae. J Bacteriol. 1979 Jul;139(1):152–160. doi: 10.1128/jb.139.1.152-160.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clarke S. D., Watkins P. A., Lane M. D. Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation. J Lipid Res. 1979 Nov;20(8):974–985. [PubMed] [Google Scholar]
  7. Claus T. H., Schlumpf J. R., el-Maghrabi M. R., Pilkis J., Pilkis S. J. Mechanism of action of glucagon on hepatocyte phosphofructokinase activity. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6501–6505. doi: 10.1073/pnas.77.11.6501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. De Wulf H., Hers H. G. The stimulation of glycogen synthesis and of glycogen synthetase in the liver by the administration of glucose. Eur J Biochem. 1967 Jul;2(1):50–56. doi: 10.1111/j.1432-1033.1967.tb00104.x. [DOI] [PubMed] [Google Scholar]
  9. El-Maghrabi M. R., Claus T. H., Pilkis J., Pilkis S. J. Partial purification of a rat liver enzyme that catalyzes the formation of fructose 2,6-bisphosphate. Biochem Biophys Res Commun. 1981 Aug 14;101(3):1071–1077. doi: 10.1016/0006-291x(81)91858-1. [DOI] [PubMed] [Google Scholar]
  10. Fletterick R. J., Madsen N. B. The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980;49:31–61. doi: 10.1146/annurev.bi.49.070180.000335. [DOI] [PubMed] [Google Scholar]
  11. Funayama S., Gancedo J. M., Gancedo C. Turnover of yeast fructose-bisphosphatase in different metabolic conditions. Eur J Biochem. 1980 Aug;109(1):61–66. doi: 10.1111/j.1432-1033.1980.tb04767.x. [DOI] [PubMed] [Google Scholar]
  12. Furuya E., Uyeda K. A novel enzyme catalyzes the synthesis of activation factor from ATP and D-fructose-6-P. J Biol Chem. 1981 Jul 25;256(14):7109–7112. [PubMed] [Google Scholar]
  13. Furuya E., Uyeda K. An activation factor of liver phosphofructokinase. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5861–5864. doi: 10.1073/pnas.77.10.5861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Furuya E., Uyeda K. Regulation of phosphofructokinase by a new mechanism. An activation factor binding to phosphorylated enzyme. J Biol Chem. 1980 Dec 25;255(24):11656–11659. [PubMed] [Google Scholar]
  15. Gancedo J. M., Gancedo C. Inactivation of gluconeogenic enzymes in glycolytic mutants of Saccharomyces cerevisiae. Eur J Biochem. 1979 Nov;101(2):455–460. doi: 10.1111/j.1432-1033.1979.tb19739.x. [DOI] [PubMed] [Google Scholar]
  16. Harris R. A. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate. Arch Biochem Biophys. 1975 Jul;169(1):168–180. doi: 10.1016/0003-9861(75)90330-6. [DOI] [PubMed] [Google Scholar]
  17. Hers H. G., Hue L., van Schaftingen E. The fructose 6-phosphate/fructose 1, 6 bisphosphate cycle. Curr Top Cell Regul. 1981;18:199–210. doi: 10.1016/b978-0-12-152818-8.50017-7. [DOI] [PubMed] [Google Scholar]
  18. Hers H. G. The control of glycogen metabolism in the liver. Annu Rev Biochem. 1976;45:167–189. doi: 10.1146/annurev.bi.45.070176.001123. [DOI] [PubMed] [Google Scholar]
  19. Hesbain-Frisque A. M., van Schaftingen E., Hers H. G. Structure and configuration of fructose 2,6-bisphosphate by 31P and 13C nuclear magnetic resonance. Eur J Biochem. 1981 Jul;117(2):325–327. doi: 10.1111/j.1432-1033.1981.tb06340.x. [DOI] [PubMed] [Google Scholar]
  20. Hue L., Blackmore P. F., Shikama H., Robinson-Steiner A., Exton J. H. Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs. J Biol Chem. 1982 Apr 25;257(8):4308–4313. [PubMed] [Google Scholar]
  21. Hue L., Hers H. G. On the use of (3H, 14C)labelled glucose in the study of the so-called "futile cycles" in liver and muscle. Biochem Biophys Res Commun. 1974 Jun 4;58(3):532–539. doi: 10.1016/s0006-291x(74)80453-5. [DOI] [PubMed] [Google Scholar]
  22. Hue L., Hers H. G. Utile and futile cycles in the liver. Biochem Biophys Res Commun. 1974 Jun 4;58(3):540–548. doi: 10.1016/s0006-291x(74)80454-7. [DOI] [PubMed] [Google Scholar]
  23. Hue L. The role of futile cycles in the regulation of carbohydrate metabolism in the liver. Adv Enzymol Relat Areas Mol Biol. 1981;52:247–331. doi: 10.1002/9780470122976.ch4. [DOI] [PubMed] [Google Scholar]
  24. Hue L., Van Schaftingen E., Blackmore P. F. Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin. Biochem J. 1981 Mar 15;194(3):1023–1026. doi: 10.1042/bj1941023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Jacob F. Evolution and tinkering. Science. 1977 Jun 10;196(4295):1161–1166. doi: 10.1126/science.860134. [DOI] [PubMed] [Google Scholar]
  26. Kagimoto T., Uyeda K. Hormone-stimulated phosphorylation of liver phosphofructokinase in vivo. J Biol Chem. 1979 Jul 10;254(13):5584–5587. [PubMed] [Google Scholar]
  27. Kagimoto T., Uyeda K. Regulation of rat liver phosphofructokinase by glucagon-induced phosphorylation. Arch Biochem Biophys. 1980 Sep;203(2):792–799. doi: 10.1016/0003-9861(80)90240-4. [DOI] [PubMed] [Google Scholar]
  28. Katz J., Rognstad R. Futile cycles in the metabolism of glucose. Curr Top Cell Regul. 1976;10:237–289. doi: 10.1016/b978-0-12-152810-2.50013-9. [DOI] [PubMed] [Google Scholar]
  29. Lane M. D., Mooney R. A. Tricarboxylic acid cycle intermediates and the control of fatty acid synthesis and ketogenesis. Curr Top Cell Regul. 1981;18:221–242. doi: 10.1016/b978-0-12-152818-8.50019-0. [DOI] [PubMed] [Google Scholar]
  30. Lederer B., Vissers S., Van Schaftingen E., Hers H. G. Fructose 2,6-bisphosphate in yeast. Biochem Biophys Res Commun. 1981 Dec 31;103(4):1281–1287. doi: 10.1016/0006-291x(81)90261-8. [DOI] [PubMed] [Google Scholar]
  31. MAKMAN R. S., SUTHERLAND E. W. ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI. J Biol Chem. 1965 Mar;240:1309–1314. [PubMed] [Google Scholar]
  32. Macy J. M., Ljungdahl L. G., Gottschalk G. Pathway of succinate and propionate formation in Bacteroides fragilis. J Bacteriol. 1978 Apr;134(1):84–91. doi: 10.1128/jb.134.1.84-91.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Malaisse W. J., Malaisse-Lagae F., Sener A. Glucose-induced accumulation of fructose-2,6-bisphosphate in pancreatic islets. Diabetes. 1982 Jan;31(1):90–93. doi: 10.2337/diab.31.1.90. [DOI] [PubMed] [Google Scholar]
  34. Malaisse W. J., Malaisse-Lagae F., Sener A. Presence of fructose-6-phosphate,2-kinase in pancreatic islets. FEBS Lett. 1981 Nov 30;135(1):203–206. doi: 10.1016/0014-5793(81)80977-5. [DOI] [PubMed] [Google Scholar]
  35. Malaisse W. J., Malaisse-Lagae F., Sener A., van Schaftingen E., Hers H. G. Is the glucose-induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofructokinase by fructose 2,6-bisphosphate? FEBS Lett. 1981 Mar 23;125(2):217–219. doi: 10.1016/0014-5793(81)80722-3. [DOI] [PubMed] [Google Scholar]
  36. Mörikofer-Zwez S., Stoecklin F. B., Walter P. Fructose 1,6-bisphosphatase in rat liver cytosol: activation after glucagon treatment in vivo and inhibition by fructose 2,6-bisphosphate in vitro. Biochem Biophys Res Commun. 1981 Jul 16;101(1):104–111. doi: 10.1016/s0006-291x(81)80016-2. [DOI] [PubMed] [Google Scholar]
  37. Müller D., Holzer H. Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation. Biochem Biophys Res Commun. 1981 Dec 15;103(3):926–933. doi: 10.1016/0006-291x(81)90899-8. [DOI] [PubMed] [Google Scholar]
  38. O'Brien W. E., Bowien S., Wood H. G. Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii. J Biol Chem. 1975 Nov 25;250(22):8690–8695. [PubMed] [Google Scholar]
  39. PASSONNEAU J. V., LOWRY O. H. Phosphofructokinase and the Pasteur effect. Biochem Biophys Res Commun. 1962 Feb 20;7:10–15. doi: 10.1016/0006-291x(62)90134-1. [DOI] [PubMed] [Google Scholar]
  40. PONTIS H. G., FISCHER C. L. SYNTHESIS OF D-FRUCTOPYRANOSE 2-PHOSPHATE AND D-FRUCTOFURANOSE 2-PHOSPHATE. Biochem J. 1963 Dec;89:452–459. doi: 10.1042/bj0890452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Pilkis S. J., El-Maghrabi M. R., McGrane M. M., Pilkis J., Claus T. H. The role of fructose 2,6-bisphosphate in regulation of fructose-1,6-bisphosphatase. J Biol Chem. 1981 Nov 25;256(22):11489–11495. [PubMed] [Google Scholar]
  42. Pilkis S. J., El-Maghrabi M. R., Pilkis J., Claus T. H., Cumming D. A. Fructose 2,6-bisphosphate. A new activator of phosphofructokinase. J Biol Chem. 1981 Apr 10;256(7):3171–3174. [PubMed] [Google Scholar]
  43. Pilkis S. J., El-Maghrabi M. R., Pilkis J., Claus T. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate. J Biol Chem. 1981 Apr 25;256(8):3619–3622. [PubMed] [Google Scholar]
  44. Pilkis S., Schlumpf J., Pilkis J., Claus T. H. Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes. Biochem Biophys Res Commun. 1979 Jun 13;88(3):960–967. doi: 10.1016/0006-291x(79)91501-8. [DOI] [PubMed] [Google Scholar]
  45. Reeves R. E., South D. J., Blytt H. J., Warren L. G. Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new enzyme with the glycolytic function of 6-phosphofructokinase. J Biol Chem. 1974 Dec 25;249(24):7737–7741. [PubMed] [Google Scholar]
  46. Richards C. S., Furuya E., Uyeda K. Regulation of fructose 2,6-P2 concentration in isolated hepatocytes. Biochem Biophys Res Commun. 1981 Jun;100(4):1673–1679. doi: 10.1016/0006-291x(81)90711-7. [DOI] [PubMed] [Google Scholar]
  47. Richards C. S., Uyeda K. Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon. Biochem Biophys Res Commun. 1980 Dec 31;97(4):1535–1540. doi: 10.1016/s0006-291x(80)80040-4. [DOI] [PubMed] [Google Scholar]
  48. SUTHERLAND E. W., RALL T. W. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem. 1958 Jun;232(2):1077–1091. [PubMed] [Google Scholar]
  49. Sabularse D. C., Anderson R. L. D-Fructose 2,6-bisphosphate: a naturally occurring activator for inorganic pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase in plants. Biochem Biophys Res Commun. 1981 Dec 15;103(3):848–855. doi: 10.1016/0006-291x(81)90888-3. [DOI] [PubMed] [Google Scholar]
  50. Sabularse D. C., Anderson R. L. Inorganic pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase in mung beans and its activation by D-fructose 1,6-bisphosphate and D-glucose 1, 6-bisphosphate. Biochem Biophys Res Commun. 1981 Jun;100(4):1423–1429. doi: 10.1016/0006-291x(81)90677-x. [DOI] [PubMed] [Google Scholar]
  51. Sawyer M. H., Baumann P., Baumann L. Pathways of D-fructose and D-glucose catabolism in marine species of Alcaligenes, Pseudomonas marina, and Alteromonas communis. Arch Microbiol. 1977 Mar 1;112(2):169–172. doi: 10.1007/BF00429331. [DOI] [PubMed] [Google Scholar]
  52. Stalmans W. The role of the liver in the homeostasis of blood glucose. Curr Top Cell Regul. 1976;11:51–97. doi: 10.1016/b978-0-12-152811-9.50009-2. [DOI] [PubMed] [Google Scholar]
  53. Söling H. D., Brand I. A. Covalent modification of phosphofructokinase by phosphorylation--dephosphorylation. Curr Top Cell Regul. 1981;20:107–138. [PubMed] [Google Scholar]
  54. Söling H. D., Kuduz J., Brand I. A. Inactivation of liver phosphofructokinase by phosphofructokinase phosphatase or by low pH is inhibited by fructose 2,6-bisphosphate. FEBS Lett. 1981 Aug 3;130(2):309–313. doi: 10.1016/0014-5793(81)81146-5. [DOI] [PubMed] [Google Scholar]
  55. Uyeda K., Furuya E., Luby L. J. The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases. J Biol Chem. 1981 Aug 25;256(16):8394–8399. [PubMed] [Google Scholar]
  56. Uyeda K., Furuya E., Sherry A. D. The structure of "activation factor" for phosphofructokinase. J Biol Chem. 1981 Aug 25;256(16):8679–8684. [PubMed] [Google Scholar]
  57. VINUELA E., SALAS M. L., SOLS A. End-product inhibition of yeast phosphofructokinase by ATP. Biochem Biophys Res Commun. 1963 Jul 18;12:140–145. doi: 10.1016/0006-291x(63)90250-x. [DOI] [PubMed] [Google Scholar]
  58. Van Schaftingen E., Hers H. G. Formation of fructose 2,6-bisphosphate from fructose 1,6-bisphosphate by intramolecular cyclisation followed by alkaline hydrolysis. Eur J Biochem. 1981 Jul;117(2):319–323. doi: 10.1111/j.1432-1033.1981.tb06339.x. [DOI] [PubMed] [Google Scholar]
  59. Van Schaftingen E., Hers H. G. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proc Natl Acad Sci U S A. 1981 May;78(5):2861–2863. doi: 10.1073/pnas.78.5.2861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Van Schaftingen E., Hers H. G. Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP. Biochem Biophys Res Commun. 1981 Aug 14;101(3):1078–1084. doi: 10.1016/0006-291x(81)91859-3. [DOI] [PubMed] [Google Scholar]
  61. Van Schaftingen E., Hers H. G. Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid. Biochem Biophys Res Commun. 1980 Oct 31;96(4):1524–1531. doi: 10.1016/0006-291x(80)91347-9. [DOI] [PubMed] [Google Scholar]
  62. Van Schaftingen E., Hue L., Hers H. G. Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase. Biochem J. 1980 Dec 15;192(3):887–895. doi: 10.1042/bj1920887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Van Schaftingen E., Hue L., Hers H. G. Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase. Biochem J. 1980 Dec 15;192(3):897–901. doi: 10.1042/bj1920897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Van Schaftingen E., Hue L., Hers H. G. Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo. Biochem J. 1980 Oct 15;192(1):263–271. doi: 10.1042/bj1920263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Van Schaftingen E., Jett M. F., Hue L., Hers H. G. Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3483–3486. doi: 10.1073/pnas.78.6.3483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. van Schaftingen E., Davies D. R., Hers H. G. Fructose-2,6-bisphosphatase from rat liver. Eur J Biochem. 1982 May;124(1):143–149. doi: 10.1111/j.1432-1033.1982.tb05917.x. [DOI] [PubMed] [Google Scholar]

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