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. 2024 Nov 23;11:1274. doi: 10.1038/s41597-024-04117-y

Table 2.

Summary of availability of clinical metadata stratified by source brain bank.

Table Name Description Brain Bank Ref [PMID]
UD HA UM MS
PD Medical History initiation and use of PD medication, changes of diagnosis over time, indication of surgeries X X X X
Family History PD indication of PD diagnosis for father, mother and/or other relatives X X
Smoking and alcohol history indication and quantification of severity of smoking and alcohol consumption X X X
Epworth Sleepiness Scale general level of daytime sleepiness X 1798888
LBD_Cohort_Clinical_Data clinical symptoms (e.g. visual hallucionations, loss of memory, mood disorder) X X X X
LBD_Cohort_Path_Data neuropathological assessments (CERADa, AD Braak, PD Braak) X X X X
MDS UPDRSb Part I non-motor symptoms covering aspects like mood, cognition and sleep X 12815652
MDS UPDRSb Part II motor symptoms impacting daily activities X X 12815652
MDS UPDRSb Part IV motor complications related to PD disease treatment X 12815652
MMSEc screening for cognitive impairment and monitoring fo changes in mental status over time X X 1202204
Modified Schwab & England (ADLd) assessment of the capabilities of people with impaired mobility X
UPDRSb other UPDRS metrics not involved in Part I-IV X 12815652

aCERAD: Consortium to Establish a Registry for Alzheimer’s Disease.

bMDS UPDRS: Movement Disorder Society – Unified Parkinson’s Disease Rating Scale.

cMMSE: Mini Mental State Examination.

dADL: Activities of Daily Living.

Complete description of all metrics at https://amp-pd.org/harmonized-clinical-assessments.