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. 2024 Nov 23;15:10163. doi: 10.1038/s41467-024-54344-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — A–E Tamoxifen was administered to animals intraperitoneally daily for 4 consecutive days. Mice were analyzed 7 days after the last injection. A Expression of B220 and CD43 in bone marrow (BM) lymphocytes from WT (n = 15) and Cre^ERRraga^fl/flRragb^fl/fl (n = 13) mice. Right, summaries of the percentages and numbers of B220^loCD43^–, B220^hiCD43^– and B220⁺CD43⁺ cells. B Expression of B220 and CD43 in BM lymphocytes from WT (n = 9) and Cre^ERRptor^fl/fl (n = 9) mice. Right, summaries of the percentages and numbers of B220^loCD43^–, B220^hiCD43^– and B220⁺CD43⁺ cells. C Expression of BP-1 and CD24 in BM B220⁺CD43⁺IgM^– B cell precursors from WT (n = 15) and Cre^ERRraga^fl/flRragb^fl/fl (n = 13) mice. Right, summary of the percentages and numbers of fraction A (CD24⁻BP-1⁻), fraction B (CD24⁺BP-1⁻), and fraction C/C′ (CD24⁺BP-1⁺) cells. D Expression of BP-1 and CD24 in BM B220⁺CD43⁺IgM^– B cell precursors from WT (n = 7) and Cre^ERRptor^fl/fl (n = 8) mice. Right, summary of the percentages and numbers of fraction A (CD24⁻BP-1⁻), fraction B (CD24⁺BP-1⁻), and fraction C/C′ (CD24⁺BP-1⁺) cells. E Expression of GL-7 and Fas in lymphocytes from the Peyer’s patches of WT (n = 12), Cre^ERRraga^fl/flRragb^fl/fl (n = 11), and Cre^ERRptor^fl/fl (n = 9) mice. Right, summary of the percentages and numbers of GC (GL-7⁺Fas⁺) B cells. Data in graphs represent mean ± SEM. ns, not significant. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, two-tailed/unpaired Student’s t-test (A and B), one-way ANOVA (E), two-way ANOVA (C and D). Source data are provided as a Source Data file.