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. 2024 Nov 23;15:10170. doi: 10.1038/s41467-024-54264-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A Cell lines were treated with 28 chemicals for 24 h and then analyzed with SPACe. The heatmap shows the Euclidean distance of each compound from the DMSO wells of each cell line. B Stacked bar graphs showing the interpretability profile of four cell line specific hit chemicals with increased features in red, decreased in blue, and unchanged in gray. C Eighteen cell lines were treated with the indicated compounds for 24 h and then Euclidean distance was calculated and represented as a heatmap. D Stacked bar graphs showing tentative “consensus fingerprints” of the changing features across a minimum of five cell lines, with increased features in red, decreased in blue, and unchanged in gray. E Selected images (zoom in from 20×/1.0 images) from one out of three independent biological replicates to showcase specific phenotypic changes caused by the indicated compounds in highlighted channels/compartments. Scale bar: 10 µm. Source data are provided as a Source Data file.