Fig. 7.

In vivo inflammatory response and histological analysis. The expression level of (A) IL-6 and (B) TNF-α determined via ELISA kit (n = 5). Note: ns signified no significant difference vs control, ∗p < 0.05 vs control, ∗∗p < 0.01 vs control, ^##p < 0.01 vs PZH MNs + NIR. (C) The heatmap of pro-inflammatory cytokine expression (n = 5). (D) H&E and (E) Gram-stained sections of infected skin tissues. The black arrows indicated the presence of Gram-positive bacteria (stained blue-purple, scale bar: 200 μm).