Fig. 2.

Association of SERPINA3 levels in epithelial and stromal tissues with the progression of disease.A Representative H&E and immunohistochemical (IHC) staining for SERPINA3 in normal and CRC colorectal tissues. Brown staining indicates SERPINA3. Scale bar = 20 μm. B Representative IHC images for SERPINA3 expression in progressive stages of rectal cancer of tissue microarray (normal, benign, tumor and metastasis). Scale bar = 50 μm. Red arrows indicate epithelial cells, while the yellow arrow highlights the stroma. C Consolidated summary graphs showing the epithelial and stromal cytoplasmic SERPINA3 expression to progressive stages of rectal cancer. Data is presented as the mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 consider statistical significance. ns = non-significant. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)