Table 3.
Joint involvement at first examination according to disease severity, age, and treatment regimens.
| Treatment regimens | Age subgroups |
Disease severity subgroups |
||||||
|---|---|---|---|---|---|---|---|---|
| 0-17 y | 18-64 y | ≥65 y | P valuea | Severe hemophilia B | Moderate hemophilia B | Mild hemophilia B | P valuea | |
| PX | ||||||||
| N | 59 | 83 | 2 | <.001 | 50 | 73 | 17 | .59 |
| Mean (SD) | 0.51 (0.84) | 1.53 (1.58) | 0.50 (0.71) | 1.32 (1.85) | 1.04 (1.16) | 0.71 (0.85) | ||
| Median (IQR) | 0 (0-1) | 1 (1-2) | 0.50 (0-NA) | 1 (0-2) | 1 (0-2) | 0 (0-1.50) | ||
| Min to max | 0-3 | 0-9 | 0-1 | 0-9 | 0-4 | 0-2 | ||
| ODT | ||||||||
| N | 26 | 36 | 4 | .009 | 5 | 35 | 25 | .29 |
| Mean (SD) | 0.12 (0.43) | 0.64 (0.90) | 0.25 (0.50) | 0.00 (0.00) | 0.51 (0.89) | 0.36 (0.64) | ||
| Median (IQR) | 0 (0-0) | 0 (0-1) | 0 (0-0.75) | 0 (0-0) | 0 (0-1) | 0 (0-1) | ||
| Min to max | 0-2 | 0-4 | 0-1 | 0-0 | 0-4 | 0-2 | ||
| ST | ||||||||
| N | 35 | 40 | 0 | .01 | 31 | 35 | 5 | .80 |
| Mean (SD) | 0.57 (0.88) | 1.23 (1.25) | - | 1.06 (1.32) | 0.80 (1.05) | 0.80 (0.84) | ||
| Median (IQR) | 0 (0-1) | 1 (0-2) | - | 1 (0-2) | 0 (0-1) | 1 (0-1.50) | ||
| Min to max | 0-4 | 0-5 | - | 0-5 | 0-4 | 0-2 | ||
max, maximum; Min, minimum; NA, not available; ODT, on-demand treatment; PX, prophylactic treatment; ST, switch from on-demand treatment to prophylaxis.
a
Kruskal–Wallis test was conducted to compare all 3 age and disease severity subgroups within each treatment group, respectively. In case of a significance, subsequent paired comparisons of age subgroups were presented in the text.