Table 4.
Number of orthopedic and other interventions on follow-up period according to treatment regimens, year, and type of intervention.
| Year of the interventiona | Orthopedic interventions |
Other interventions | Total | ||
|---|---|---|---|---|---|
| Major surgery | Minor surgery | RS | |||
| PX | |||||
| 1993-2006 | 6 | 2 | 11 | 25 | 44 |
| 2007-2018 | 19 | 4 | 39 | 93 | 155 |
| Year unknown | 0 | 0 | 9 | 21 | 30 |
| Subtotal | 25 | 6 | 59 | 139 | 229 |
| ODT | |||||
| 1993-2006 | 0 | 0 | 0 | 11 | 11 |
| 2007-2018 | 4 | 1 | 3 | 35 | 43 |
| Year unknown | 3 | 0 | 3 | 8 | 14 |
| Subtotal | 7 | 1 | 6 | 54 | 68 |
| ST | |||||
| 1993-2006 | 2 | 3 | 11 | 15 | 31 |
| 2007-2018 | 4 | 5 | 11 | 36 | 56 |
| Year unknown | 0 | 0 | 0 | 4 | 4 |
| Subtotal | 6 | 8 | 22 | 55 | 91 |
| Patients with no treatment details | 2 | 0 | 0 | 6 | 8 |
| Total | 40 | 15 | 87 | 254 | 396 |
ODT, on-demand treatment; PX, prophylactic treatment; RS, radiosynovectomy; ST, switch from on-demand treatment to prophylaxis.
a
Year of intervention was grouped into 2 periods based on the accessibility to factor replacement therapy in Turkey: 1993-2006, a limited number of factor concentrates were available through a named patient program; 2007-2018, factor replacement therapy became widely available following reimbursement.