Table 3.
Univariate and Multivariate Analyses of Factors Associated with Overall Survival
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age | 1.035 | 1.023–1.048 | <0.001 | 1.041 | 1.027–1.055 | <0.001 |
| Gender | ||||||
| Male vs Female | 1.010 | 0.733–1.393 | 0.950 | |||
| Diabetes mellitus | ||||||
| Yes vs no | 1.484 | 1.091–2.019 | 0.012 | 1.424 | 1.039–1.950 | 0.028 |
| BMI | 0.998 | 0.947–1.051 | 0.940 | |||
| FIB-4 score | 1.037 | 1.015–1.060 | 0.001 | NS | ||
| ALBI score | 2.092 | 1.645–2.659 | <0.001 | 2.078 | 1.600–2.698 | <0.001 |
| HBV DNA | ||||||
| Detectable vs undetectable | 0.935 | 0.688–1.308 | 0.694 | |||
| qHBsAg (IU/mL) | 0.910 | 0.804–1.031 | 0.138 | |||
| HBeAg | ||||||
| Positive vs negative | 0.997 | 0.588–1.692 | 0.993 | |||
| NUC therapy | ||||||
| Yes vs No | 0.633 | 0.464–0.864 | 0.004 | NS | ||
| Tumor size | 1.381 | 1.187–1.606 | <0.001 | 1.203 | 1.030–1.404 | 0.019 |
| Tumor number | ||||||
| Multiple vs single | 1.318 | 0.852–2.041 | 0.215 | |||
| AFP (log ng/mL) | 1.254 | 1.048–1.550 | 0.013 | 1.404 | 1.161–1.698 | <0.001 |
| Creatinine (mg/dL) | 1.156 | 1.073–1.246 | <0.001 | 1.234 | 1.141–1.336 | <0.001 |
| ALT | 1.001 | 0.993–1.008 | 0.826 | |||
| AST | 1.006 | 0.998–1.014 | 0.116 | |||
| Tumor location | ||||||
| Subcapsular | 1.033 | 0.774–1.380 | 0.825 | |||
| Near gallbladder or hilum | 1.870 | 1.175–2.977 | 0.008 | NS | ||
| Near bowel | 1.152 | 0.626–2.119 | 0.650 | |||
| Near major vessel | 0.883 | 0.630–1.237 | 0.469 | |||
Abbreviations: HR, hazard ratio; CI, confidence interval; NS, not significant; ALBI, Albumin-Bilirubin.