Table 3.
Histopathologic Parameters of Patients who Underwent Rectal Cancer Surgery
| Histopathologic Parameters | R (n=15) | L (n=15) | O (n=15) | p-value |
|---|---|---|---|---|
| Histology | ||||
| Adenocarcinoma | 15 (100%) | 15 (100%) | 15 (100%) | - |
| Well-differentiated | 8 (53.33%) | 7 (46.67%) | 7 (46.67%) | - |
| Moderately differentiated | 5 (33.33%) | 8 (53.33%) | 7 (46.67%) | - |
| Poorly differentiated | 2 (13.33%) | 0 (0%) | 1 (6.67%) | - |
|
| ||||
| Resection margin | 0.1230 | |||
| R0 | 13 (86.67%) | 15 (100%) | 15 (100%) | |
| R1 | 2 (13.33%) | 0 (0%) | 0 (0%) | |
| R2 | 0 (0%) | 0 (0%) | 0 (0%) | |
|
| ||||
| Circumferential resection margin | 0.0310 | |||
| Positive (Less than 1 mm) | 4 (30.77%) | 1 (6.67%) | 0 (0%) | |
| Negative | 9 (69.23%) | 14 (93.33%) | 15 (100%) | |
| Undetermined/Not reported | 2 (13.33%) | 0 (0%) | 0 (0%) | |
|
| ||||
| Proximal resection margin (cm) | Mean 11.10 | Mean 6.73 | Mean 5.37 | 0.0002 |
| Range 2-16.5 | Range 3.5-11 | Range 2.5-11 | ||
| SD ±4.77 | SD ±2.84 | SD ±2.70 | ||
|
| ||||
| Bonferroni multiple comparison | ||||
| R > O (p-value <0.001) | ||||
| R > L (p-value 0.005) | ||||
| L vs O (p-value 0.06) | ||||
|
| ||||
| Distal resection margin (cm) | Mean 2.45 | Mean 2.55 | Mean 3.87 | 0.0819 |
| Range 0.1-5 | Range 0-8 | Range 1-7.5 | ||
| SD ±1.78 | SD ±1.93 | SD ±1.78 | ||
|
| ||||
| Lymph node harvest | Mean 11.40 | Mean 15.20 | Mean 16.93 | 0.01 |
| Range 3-20 | Range 3-27 | Range 2-34 | ||
| SD ±4.40 | SD ±7.27 | SD ±10.65 | ||
|
| ||||
| Bonferroni multiple comparison | ||||
| O vs L (p-value 0.07) | ||||
| L > R (p-value <0.001) | ||||
| O > R (p-value <0.001) | ||||
|
| ||||
| Positive lymph node harvest | Mean 9.21% | Mean 9.15% | Mean 7.93% | 0.8844 |
| Range 0%-50% | Range 0%-77% | Range 0%-33% | ||
| SD ±15.85% | SD ±20.27% | SD ±12.17% | ||
|
| ||||
| Perineural invasion | 0.5660 | |||
| Yes | 2 (15.38%) | 1 (6.67%) | 3 (20.00%) | |
| No | 11 (73.33%) | 14 (93.33%) | 12 (80.00%) | |
| Undetermined | 2 (13.33%) | 0 (0%) | 0 (0%) | |
|
| ||||
| Lymphovascular invasion | 0.0010 | |||
| Yes | 3 (23.08%) | 12 (80.00%) | 10 (66.67%) | |
| No | 10 (76.92%) | 3 (20.00%) | 5 (33.33%) | |
| Undetermined | 2 (13.33%) | 0 (0%) | 0 (0%) | |
|
|
||||
| Bonferroni multiple comparison L > R (p-value <0.0010) O > R (p-value <0.0020) L vs O (p-value – 0.09) |
||||
R – robot-assisted rectal surgery; L – laparoscopic surgery; O – open surgery