Fig. 1.

GFAP expression across diagnostic status. Cortical GFAP mRNA and protein are higher in those with a clinical or pathologic AD diagnosis than controls, while caudate expression values do not differ across diagnoses. A Final summary clinical diagnosis: normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD). B Pathologic diagnosis according to neuropathologic staging (CERAD and Braak) NIA-Reagan criteria. Positive: high or intermediate likelihood of AD and negative: low likelihood or no AD. Significance values are derived from pairwise Student t tests and FDR-corrected results. ns: p > 0.05. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001