Table 2.
Main effects of GFAP expression on AD core pathology
| Predictor | Outcome | β | SE | p value | P.fdr |
|---|---|---|---|---|---|
| dlPFC mRNA | Aβ1-42 | 0.157 | 0.0296 | 1.34e−07 | 2.94e−06 |
| dlPFC mRNA | Neuritic plaque | 0.0668 | 0.0140 | 2.25e−06 | 3.71e−05 |
| dlPFC protein | Aβ1-42 | 0.934 | 0.170 | 7.80e−8 | 2.57e−06 |
| dlPFC protein | Neuritic plaque | 0.439 | 0.0705 | 1.20e−9 | 7.92e−08 |
| CN mRNA | Aβ1-42 | 0.119 | 0.0702 | 9.08e−02 | 1.43e−01 |
| CN mRNA | Neuritic plaque | 0.0520 | 0.0322 | 1.07e−01 | 1.64e−01 |
| PCC mRNA | Aβ1-42 | 0.191 | 0.0497 | 1.39e−04 | 5.75e−04 |
| PCC mRNA | Neuritic plaque | 0.0965 | 0.0234 | 4.33e−05 | 2.86e−04 |
| dlPFC mRNA | p-Tau, AT8 | 0.138 | 0.0352 | 9.23e−05 | 4.06e−04 |
| dlPFC mRNA | Neurofibrillary tangles | 0.0437 | 0.0108 | 5.90e−05 | 3.24e−04 |
| dlPFC protein | p-Tau, AT8 | 0.479 | 0.142 | 7.99e−04 | 2.64e−03 |
| dlPFC protein | Neurofibrillary tangles | 0.213 | 0.0522 | 5.45e−05 | 3.24e−04 |
| CN mRNA | p-Tau, AT8 | 0.104 | 0.0797 | 1.92e−01 | 2.76e−01 |
| CN mRNA | Neurofibrillary tangles | 0.0331 | 0.0249 | 1.84e−01 | 2.76e−01 |
| PCC mRNA | p-Tau, AT8 | 0.217 | 0.0548 | 8.78e−05 | 4.06e−04 |
| PCC mRNA | Neurofibrillary tangles | 0.0723 | 0.0173 | 3.39e−05 | 2.68e−04 |
| Models adjusting for astrocyte transcript fraction | |||||
| dlPFC mRNA | Aβ1-42 | 0.2178 | 0.0464 | 3.57e−06 | 4.71e−05 |
| dlPFC mRNA | Neuritic plaque | 0.1004 | 0.0224 | 9.79e−06 | 9.86e−05 |
| dlPFC mRNA | p-Tau, AT8 | 0.184 | 0.0532 | 5.91e−04 | 2.15e−03 |
| dlPFC mRNA | Neurofibrillary tangles | 0.0587 | 0.0164 | 3.72e−04 | 1.44e−03 |
Boldface signifies p < 0.05
dlPFC dorsolateral prefrontal cortex, CN caudate nucleus, PCC posterior cingulate cortex