Table 3.
Main effects of GFAP expression on cognition
| Predictor | Outcome | β | SE | p value | P.fdr |
|---|---|---|---|---|---|
| dlPFC mRNA | Cross-sectional cognition | −0.0599 | 0.0301 | 4.67e−02 | 9.06e−02 |
| dlPFC mRNA | Longitudinal cognition | −0.0094 | 0.0029 | 1.10e−03 | 3.29e−03 |
| dlPFC protein | Cross-sectional cognition | −0.423 | 0.155 | 6.83e−03 | 1.88e−02 |
| dlPFC protein | Longitudinal cognition | −0.0549 | 0.0124 | 1.046e−05 | 9.86e−05 |
| CN mRNA | Cross-sectional cognition | −0.0593 | 0.0670 | 3.77e−01 | 4.88e−01 |
| CN mRNA | Longitudinal cognition | −0.0056 | 0.0066 | 3.92e−01 | 4.91e−01 |
| PCC mRNA | Cross-sectional cognition | −0.1584 | 0.0476 | 9.54e−04 | 2.30e−03 |
| PCC mRNA | Longitudinal cognition | −0.0176 | 0.0044 | 6.69e−05 | 3.40e−04 |
| Models adjusting for astrocyte transcript fraction | |||||
| dlPFC mRNA | Cross-sectional cognition | −0.102 | 0.0464 | 2.79e−2 | 6.14e−02 |
| dlPFC mRNA | Longitudinal cognition | −0.0107 | 0.00510 | 3.52e−2 | 7.37e−02 |
Boldface signifies p < 0.05
dlPFC dorsolateral prefrontal cortex, CN caudate nucleus, PCC posterior cingulate cortex