Table 4.

Interactions of GFAP and amyloid status on tau and cognition

Predictor	Outcome	β	SE	p value	P.fdr
dlPFC mRNA x amyloid status	p-Tau, AT8	0.173	0.0665	9.36e−03	2.47e−02
dlPFC protein x amyloid status	p-Tau, AT8	0.506	0.295	8.70e−02	1.40e−01
CN mRNA x amyloid status	p-Tau, AT8	0.0716	0.149	6.31e−01	7.31e−01
PCC mRNA x amyloid status	p-Tau, AT8	0.196	0.103	5.60e−02	1.03e−01
dlPFC mRNA x amyloid status	Longitudinal cognition	−0.0118	0.0056	3.58e−02	7.37e−02
dlPFC protein x amyloid status	Longitudinal cognition	−0.0649	0.0272	1.71e−02	4.03e−02
CN mRNA x amyloid status	Longitudinal cognition	0.0003	0.0128	9.82e−01	9.93e−01
PCC mRNA x amyloid status	Longitudinal cognition	−0.0035	0.0086	6.86e−01	7.67e−01

Boldface signifies p < 0.05

Amyloid status is defined by a binary variable where amyloid negativity = CERAD “none” or “sparse” and amyloid positivity = CERAD “moderate” or frequent”

dlPFC dorsolateral prefrontal cortex, CN caudate nucleus, PCC posterior cingulate cortex