Fig. 4.

Correlations of in vivo PET signals with tau abundance and autoradiography signals in autopsy samples. a Basal ganglia AT8 immunohistochemistry together with [¹⁸F]PI-2620 autoradiography of adjacent sections and axial [¹⁸F]PI-2620 tau PET signals in basal ganglia sections prior to death. Images are shown for all seven investigated patients with definite PSP and two patients with TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal lobar degeneration (FTLD-TDP): one with FTLD/MND-TDP and one with FTLD-TDP related to a TANK-binding kinase 1 (TBK1) mutation. b Frontal medial gyrus AT8 immunohistochemistry together with [¹⁸F]PI-2620 autoradiography of adjacent sections and axial [¹⁸F]PI-2620 tau PET signals in cortical sections prior to death. Images are displayed for seven patients with definite PSP and two disease controls, as indicated in (A). c Multimodal quantitative partial correlation between tau abundance, autoradiography signals and tau PET signals. Linear regression lines (including 95% confidence intervals) were calculated, taking into account the globus pallidus and frontal medial gyrus as cofactors, in samples derived from seven patients with definite PSP, one patient with FTLD/MND-TDP, and one patient with FTLD related to a TBK1 mutation. R indicates Pearson’s correlation coefficient. %N/Area-% = AT8 occupancy of neurofibrillary tangles and coiled bodies